The effect of indoor environment on acute exacerbations of chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XIE Guogang , JIN Xianqiao

Department of Respiratory Medicine，Affiliated First People’s Hospital，Shanghai Jiaotong University.Shanghai，200080，China Corresponding author ： JIN xian-qiao ， E-mail ： jinxianqiao@hotmail.com;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Acute exacerbation; Indoor environment; Temperature; Relative humidity

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Objective To evaluate the effects of indoor temperature and relative humidity on acute exacerbations of chronic obstructive pulmonary disease（AECOPD）.Methods A total of 70 moderate to very severe COPD patients were recruited.The data including indoor temperature and relative humidity twice daily，increase over their stable symptoms in "major" symptoms（dyspnea，sputum purulence，sputum amount） and "minor" symptoms（nasal discharge/congestion，sore throat，cough），and adjustment of medication were recorded on diary cards.All data were collected from Jan 2005 to Dec 2005 by telephone inquiring or home visiting.Furthermore，the corresponding median outdoor temperature，relative humidity and air pressure from atmosphere bureau were compared with indoors parameters to examine the different effects on AECOPD.Results Fifty-five cases completed the whole investigation.Indoor temperature and relative humidity were both risk factors when logistic regression was used to evaluate the effect.Our research showed that AECOPD was significantly related to indoor and ourdoor environment factors.The correlation coefficient of all factors were r=－0.686（indoor temperature），r=－0.671（outer temperature），r=0.105（indoor humidity），r=－0.115（outer humidity），r=0.545（atmospheric pressure） respectively.Conclusions The indoor temperature and relative humidity，especially low temperature and high relative humidity，had important effects on AECOPD of moderate to very severe patients.It may be helpful to prevent AECOPD by adjusting the indoor temperature and relative humidity.

Citation： XIE Guogang ,JIN Xianqiao. The effect of indoor environment on acute exacerbations of chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(5): 358-362. doi: Copy

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1. 赵鸣武，重视对慢性阻塞性肺疾病急性加重的病因学及其对策的研究．中国呼吸与危重监护杂志，2004，3：67.
2. . 刘春涛，冯玉麟．慢性阻塞性肺疾病急性加重研究进展．中国呼吸与危重监护杂志，2007，6：413-415.
3. Fabbri LM，Hurd SS.Global strategy for the diagnosis，management and prevention of COPD：2003 update.Eur Respir J，2003，22：1-2.
4. Anthonisen NR，Manfreda J，Warren CP，et al.Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease.Ann Intern Med，1987，106：196-204.
5. Edwin K.Exacerbations in Chronic Obstructive Pulmonary Disease：Do They Contribute to Disease Progression? Proc Am Thorac Soc，2007，4：586-590.
6. Seemungal TAR，Donaldson GC，Paul EA，et al.Rrelationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease.Thorax，2002，57：847-852.
7. Seemungal TA，Donaldson GC，Bhowmik A，et al.Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease.Am J Resp ir Crit Care Med，2000，161：1608-1613.
8. Donaldson GC，Wedzicha JA.COPD exacerbations.1：epidemiology.Thorax，2006，61：164-168.
9. Koskela H，Jussi P，Heikki P，et al.Effect of cold air on exercise capacity in COPD.Chest，1998，113：1560–1565.
10. 曾运红，郭兰萍，张羽，等.慢性阻塞性肺疾病发病住院与气候因素的关系.广东医学，2003，24：1230-1231.
11. Donaldson GC，Seemungal T，Jeffries DJ，et al.Effect of environmental temperature on symptoms，lung function and mortality in COPD patients.Eur Respir J，1999，13：844–849.

Chinese Journal of Respiratory and Critical Care Medicine

The effect of indoor environment on acute exacerbations of chronic obstructive pulmonary disease

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