Some Issues on Mechanical Ventilation in Surving Sepsis Campaign Guideline 2008_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LI Yimin , HE Guoqing

The State Key Lab. of Respiratory Disease，Guangzhou Institute of Respiratory Disease，The First Affiliated Hospital，Guangzhou Medical College. Guangzhou, Guangdong, 510120，China;

Corresponding author：

Keywords：

sepsis; Mechanical ventilation

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Sepsis 已经成为危重症医学中较为常见的一种综合征，它定义为因病原体感染而引起的全身性炎症反应综合征。严重Sepsis患者预后不佳，治疗上也较为困难，特别是合并Septic Shock和多器官功能不全综合征（MODS）的患者，死亡率仍然较高，因此近年来在临床及研究上均已引起明显的重视。为了能促进Sepsis的研究及治疗，国际上多个医学专科分会联合发起“拯救Sepsis运动（Surviving Sepsis Campaign, SSC）”，并于2004年首次发表了相应的指南，即Surviving Sepsis Campaign Guideline for Management of Severe Sepsis and Septic Shock。今年初SSC再次发表了新版的指南，主要是结合近年的研究成果而在原版的基础上进行适当的补充和更新，以指导临床上严重Sepsis的抢救及治疗。

Citation： LI Yimin,HE Guoqing. Some Issues on Mechanical Ventilation in Surving Sepsis Campaign Guideline 2008. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(2): 101-103. doi: Copy

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3.	、 Villar J, Kacmarek RM, Perez-Mendez L, et al. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial. Crit Care Med.
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1. 、 The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med.
2. 、 Ferguson ND, Frutos-Vivar F, Esteban A, et al. Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med.
3. 、 Villar J, Kacmarek RM, Perez-Mendez L, et al. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial. Crit Care Med.
4. 、 van den Berg PC, Jansen JR, Pinsky MR. Effect of positive pressure on venous return in volume-loaded cardiac surgical patients. J Appl Physiol.
5. 、 George DL, Falk PS, Wunderink RG, et al. Epidemiology of ventilator acquired pneumonia based on protected bronchoscopic sampling. Am J Respir Crit Care Med.
6. ; 158:1839-1847Safdar N, Said A, Lucey MR. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl.
7. ; 342: 1301-1308.
8. ; 92: 1223-1231.
9. ; 10817-827.
10. ; 33: 21-30.
11. ; 34: 1311-1318.

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