COPD患者血浆白细胞介素-13与白三烯B4水平变化的研究_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

于颍佳 ,  许西琳

Corresponding author：

许西琳, Email: xuxilin@yahoo.com.cn

Keywords：

慢性阻塞性肺疾病; 白细胞介素13; 白三烯B4

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目的探讨COPD 患者急性加重期和稳定期血浆IL-13 与白三烯B4 ( LTB4 ) 水平的变化。方法收集符合纳入标准的COPD 患者30 例, 以健康志愿者30 例作为对照。比较COPD 患者急性加重期、稳定期血浆IL-13 与LTB4 水平, 并与正常对照组比较, 对IL-13 与LTB4 进行相关分析。结果 COPD 急性加重期患者血浆IL-13 与LTB4 水平分别为( 31. 13 ±4. . 59) pg/mL 和( 339. 52 ±45. 50) pg/mL, 在稳定期分别为( 20. 72 ±4. 39) pg/mL 和( 196. 71 ±53. 85) pg/mL, 均较正常对照组显著增高[ ( 6.04 ±1. 58) pg/mL 和( 63. 36 ±11. 82) pg/mL, P 均 lt; 0. 05] , 急性加重期IL-13 与LTB4水平显著高于稳定期( P 均 lt;0. 05) 。急性加重期和稳定期血浆IL-13 水平与LTB4 水平均呈明显正相关( r =0. 985, r =0. 970; P = 0. 000) 。结论 IL-13 和LTB4 可以作为反映COPD 病情的免疫学指标, 可通过监测IL-13 和LTB4 水平来反映病情变化及指导治疗。

Citation： 于颍佳,许西琳. COPD患者血浆白细胞介素-13与白三烯B4水平变化的研究. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(2): 190-191. doi: Copy

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1. Barnett M.Management of end-stage chronic obstructive pulmonary disease. Br J Nurs, 2008, 17: 1390-1394.
2. Sadeghnejad A, Meyers DA, Bottai M, et al. IL-13 promoter polymorphism 1112C/ T modulates the adverse effect of tobacco smoking on lung function. AmJ Respir Crit Care Med, 2007,176:748-752.
3. Rubin P, Mollison KW. Pharmacotherapy of diseases mediated by 5 -lipoxygenase pathway eicosanoids. Prostaglandins Other Lipid Mediat, 2007, 83: 188-197.
4. Zheng T, Zhu Z, Wang Z, et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest, 2000, 106: 1081-1093.
5. Hacievliyagil SS, Gunen H, Mutlu LC, et al. Association between cytokines in induced sputum and severity of chronic obstructive pulmonary disease. Respir Med, 2006, 100: 846-854.
6. Bowles KS, Beadle RE, Mouch S, et al. A novel model of equine recurrent airway obstruction. Vet Immunol Immunopathol, 2002, 87:385-389.
7. Cohn L, Whittaker L, Niu N, et al. Cytokine regulation of mucus production in a model of allergic asthma. Novartis Found Symp,2002, 248: 201-213.
8. Tanino M, Betsuyaku T, Takeyabu K, et al. Increased levels of interleukin-8 in BAL fluid from smokers susceptible pulmonary emphysema. Thorax, 2002, 57: 405-411.
9. Beeh KM, Kornmann O, Buhl R, et al. Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. Chest, 2003, 123: 1240-1247.
10. Vargaftig BB, Singer M. Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. Am J Physiol Lung Cell Mol Physiol, 2003, 284: L260-L269.
11. Vargaftig BB, Singer M. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol, 2003, 28: 410-419.

Chinese Journal of Respiratory and Critical Care Medicine

COPD患者血浆白细胞介素-13与白三烯B4水平变化的研究

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