呼出气一氧化氮检测技术的前景: 阳光灿烂还是阴云密布?_Chinese Journal of Respiratory and Critical Care Medicine

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刘春涛

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无创检测; 一氧化氮; 哮喘

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Citation： 刘春涛. 呼出气一氧化氮检测技术的前景: 阳光灿烂还是阴云密布?. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(4): 318-321. doi: Copy

1.	Sont JK, Han J, van Krieken JM, et al. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. thorax,1996, 51: 496-502.
2.	Takalo R, Piiril　P, Sovij　rvi AR. Repeatability of successive measurements with a portable nitric oxide analyser in patients with suggested or diagnosed asthma. Scand J Clin Lab Invest, 2008, 68:830-832.
3.	Silkoff PE, Erzurum SC, Lundberg JO, et al. American Thoracic Society; HOC Subcommittee of the Assembly on Allergy,Immunology, and Inflammation. ATS workshop proceedings:exhaled nitric oxide and nitric oxide oxidative metabolismin exhaled breath condensate. Proc Am Thorac Soc, 2006, 3: 131-145.
4.	Lim KG, Mottram C. The use of fraction of exhaled nitric oxide in pulmonary practice. Chest, 2008, 133: 1232-1342.
5.	Price D, Berg J, Lindgren P. An economic evaluation of NIOX MINO airway inflammation monitor in the United Kingdom. Allergy, 2009 ,64: 431-438.
6.	Smith AD, Cowan JO, Filsell S, et al. Diagnosing asthma:comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med, 2004, 169: 473 -478.
7.	Berkman N, Avital A, Breuer R, et al. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests.Thorax, 2005, 60: 383-388.
8.	Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma.Chest, 2003, 123: 751-756.
9.	Schneider A, Tilemann L, Schermer, et al. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study. Respir Res, 2009 , 10: 15.
10.	Bush A, Eber E. The value of FeNO measurement in asthma management: the motion for Yes, it’s NO-or, the wrong end of the Stick! Paediatr Respir Rev, 2008 , 9: 127-131 .
11.	Khalili B, Boggs PB, Shi R, et al. Discrepancy between clinical asthma control assessment tools and fractional exhaled nitric oxide.Ann Allergy Asthma Immunol, 2008, 101: 124-129.
12.	Smith AD, Cowan JO, Brassett KP, et al. Exhaled Nitric Oxide A Predictor of Steroid Response. Am J Respir Crit Care Med, 2005 ,172: 453-459.
13.	Bodini A, Peroni D, Loiacono A, et al. Exhaled nitric oxide daily evaluation is effective in monitoring exposure to relevant allergens in asthmatic children. Chest, 2007, 132: 1520-1525.
14.	Harkins MS, Fiato KL, Iwamoto GK. Exhaled nitric oxide predicts asthma exacerbation. J Asthma, 2004, 41: 471-476.
15.	Singh D, Richards D, Knowles RG, et al. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am J Respir Crit Care Med, 2007, 176: 988-993.
16.	Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.Am J Respir Crit Care Med, 2007, 176: 231-237.
17.	Jayaram L, Pizzichini MM, Cook RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J, 2006, 27: 483-494.
18.	Smith AD, Cowan JO, Brassett KP, et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl JMed,2005, 352: 2163-2173.
19.	Pijnenburg MW, Bakker EM, Hop WC, et al. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. . Am J Respir Crit Care Med, 2005, 172: 831-836.
20.	de Jongste JC, Carraro S, Hop WC, et al. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med, 2009, 179: 93-97.
21.	Gibson PG. Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies. Clin Exp Allergy, 2009, 39: 478-490.
22.	Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a andomised controlled trial. Lancet, 2008, 372: 1065-1072.
23.	Franklin PJ, Stick SM. The value of FeNO measurement in asthma management: the motion against FeNO to help manage childhood asthma--reality bites. Paediatr Respir Rev, 2008, 9: 122-126.
24.	Taylor DR. Exhaled NO: forward, backward, or sideways? Am J Respir Crit Care Med, 2007, 176: 221-222.
25.	Taylor DR. Exhaled nitric oxide: still alive, not laid to rest. Am J Respir Crit Care Med, 2009, 179: 88-89.
26.	Moore WC. Update in Asthma 2007. Am J Respir Crit Care Med,2008, 177: 1068-1073.

1. Sont JK, Han J, van Krieken JM, et al. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. thorax,1996, 51: 496-502.
2. Takalo R, Piiril　P, Sovij　rvi AR. Repeatability of successive measurements with a portable nitric oxide analyser in patients with suggested or diagnosed asthma. Scand J Clin Lab Invest, 2008, 68:830-832.
3. Silkoff PE, Erzurum SC, Lundberg JO, et al. American Thoracic Society; HOC Subcommittee of the Assembly on Allergy,Immunology, and Inflammation. ATS workshop proceedings:exhaled nitric oxide and nitric oxide oxidative metabolismin exhaled breath condensate. Proc Am Thorac Soc, 2006, 3: 131-145.
4. Lim KG, Mottram C. The use of fraction of exhaled nitric oxide in pulmonary practice. Chest, 2008, 133: 1232-1342.
5. Price D, Berg J, Lindgren P. An economic evaluation of NIOX MINO airway inflammation monitor in the United Kingdom. Allergy, 2009 ,64: 431-438.
6. Smith AD, Cowan JO, Filsell S, et al. Diagnosing asthma:comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med, 2004, 169: 473 -478.
7. Berkman N, Avital A, Breuer R, et al. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests.Thorax, 2005, 60: 383-388.
8. Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma.Chest, 2003, 123: 751-756.
9. Schneider A, Tilemann L, Schermer, et al. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study. Respir Res, 2009 , 10: 15.
10. Bush A, Eber E. The value of FeNO measurement in asthma management: the motion for Yes, it’s NO-or, the wrong end of the Stick! Paediatr Respir Rev, 2008 , 9: 127-131 .
11. Khalili B, Boggs PB, Shi R, et al. Discrepancy between clinical asthma control assessment tools and fractional exhaled nitric oxide.Ann Allergy Asthma Immunol, 2008, 101: 124-129.
12. Smith AD, Cowan JO, Brassett KP, et al. Exhaled Nitric Oxide A Predictor of Steroid Response. Am J Respir Crit Care Med, 2005 ,172: 453-459.
13. Bodini A, Peroni D, Loiacono A, et al. Exhaled nitric oxide daily evaluation is effective in monitoring exposure to relevant allergens in asthmatic children. Chest, 2007, 132: 1520-1525.
14. Harkins MS, Fiato KL, Iwamoto GK. Exhaled nitric oxide predicts asthma exacerbation. J Asthma, 2004, 41: 471-476.
15. Singh D, Richards D, Knowles RG, et al. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am J Respir Crit Care Med, 2007, 176: 988-993.
16. Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.Am J Respir Crit Care Med, 2007, 176: 231-237.
17. Jayaram L, Pizzichini MM, Cook RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J, 2006, 27: 483-494.
18. Smith AD, Cowan JO, Brassett KP, et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl JMed,2005, 352: 2163-2173.
19. Pijnenburg MW, Bakker EM, Hop WC, et al. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. . Am J Respir Crit Care Med, 2005, 172: 831-836.
20. de Jongste JC, Carraro S, Hop WC, et al. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med, 2009, 179: 93-97.
21. Gibson PG. Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies. Clin Exp Allergy, 2009, 39: 478-490.
22. Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a andomised controlled trial. Lancet, 2008, 372: 1065-1072.
23. Franklin PJ, Stick SM. The value of FeNO measurement in asthma management: the motion against FeNO to help manage childhood asthma--reality bites. Paediatr Respir Rev, 2008, 9: 122-126.
24. Taylor DR. Exhaled NO: forward, backward, or sideways? Am J Respir Crit Care Med, 2007, 176: 221-222.
25. Taylor DR. Exhaled nitric oxide: still alive, not laid to rest. Am J Respir Crit Care Med, 2009, 179: 88-89.
26. Moore WC. Update in Asthma 2007. Am J Respir Crit Care Med,2008, 177: 1068-1073.

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呼出气一氧化氮检测技术的前景: 阳光灿烂还是阴云密布?

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