阻塞性睡眠呼吸暂停综合征( obstructive sleep apnea syndrome, OSAS) 是一种常见的睡眠呼吸障碍性疾病, 在成人发生率为2% ～4% , 由于睡眠中反复发生上气道部分或完
全阻塞而表现为夜间间断低氧和高碳酸血症、反复觉醒、睡眠结构紊乱, 临床上常引起心、脑、肾等多器官损害。越来越多的证据表明, OSAS并发高血压、冠心病、肺动脉高压、心力衰竭、中风的危险性增高, 是心脑血管疾病的独立危险因素。未经治疗的重度OSAS 患者5 年病死率高达11% ～13% , 而心脑血管并发症是主要死因。如果及时给予有效治疗, 在一定程度上可以预防并发症的发生, 甚至逆转心脑血管并发症的转归。
Citation：
WANG Wei. Obstructive Sleep Apnea Sysndrome and Hypertension. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 1-2. doi:
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- 1. Somers VK,White DP, Amin R, et al. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, StrokeCouncil, and Council on Cardiovascular Nursing. J Am Coll Cardiol,2008, 52: 686-717.
- 2. Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med, 2000, 342: 1378-1384.
- 3. Lavie P, Herer P, Hoffstein V. Obstructive sleep apnea syndrome as a risk factor for hypertension: population study. Br Med J, 2000 , 320 :479- 482.
- 4. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 睡眠呼吸暂停人群高血压患病率的多中心研究. 中华结核和呼吸杂志, 2007, 30:894-897.
- 5. 宋秀萍, 张军英. 睡眠呼吸暂停综合征合并高血压的临床特点观察. 临床和实验医学杂志, 2008, 12, 72-73.
- 6. Das AM, Khayat R. Hypertension in obstructive sleep apnea: risk and therapy. Expert Rev Cardiovasc Ther, 2009, 7: 619-626.
