Sleep Breathing Disorder，Coronary Heart Disease and Cardiac Arrtythmia_Chinese Journal of Respiratory and Critical Care Medicine

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WANG Bei

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Keywords：

睡眠呼吸障碍; 冠心病; 心律失常

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睡眠呼吸障碍（sleep breathing disorders，SDB）是一种常见病、多发病，其主要类型是阻塞性睡眠呼吸暂停综合征（OSAS），特点是夜间睡眠过程中上气道完全或部分阻塞及呼吸中枢驱动降低导致呼吸暂停及低通气，产生慢性间歇性低氧、反复微觉醒、睡眠结构异常、自主神经功能紊乱等。OSAS近年已公认是一种全身性疾病，它可引起或加重许多疾病,美国心脏协会/美国心脏病学基金会（AHA/ACCF）联合发表了《睡眠呼吸暂停与心血管疾病的科学共识》。为了进一步认识两者之间的关系，提升OSAS及相关疾病防控水平，中华医学会呼吸病分会睡眠学组与心血管病学组就SDB与心血管疾病相关问题达成共识，为多学科联合防治SDB提供了科学依据。

Citation： WANG Bei. Sleep Breathing Disorder，Coronary Heart Disease and Cardiac Arrtythmia. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 2-4. doi: Copy

1.	Young T,Evans L,Finn L,et al.Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women.Sleep,1997,20:705-706.
2.	Bixler EO,Vgontzas AN,Ten Have T,et al.Effects of age on sleep apnea in men: I.Prevalence and severity.Am J Respir Crit Care Med,1998,157:144-148.
3.	Hu FB,Willett WC,Manson JE,et al.Snoring and risk of cardiovascular disease in women. J Am Coll Cardiol,2000,35:308-313.
4.	Nieto FJ,Young TB,Lind BK,et al.Association of sleep-disordered breathing,sleep apnea,and hypertension in a large community-based study.Sleep Heart Health Study.JAMA,2000,283:1829-1836.
5.	Elmasry A,Lindberg E,Berne C,et al.Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study.J Intern Med,2001,249:153-161.
6.	Hu FB,Willett WC,Colditz GA,et al.Prospective study of snoring and risk of hypertension in women.Am J Epidemiol,1999,150:806-816.
7.	Wilcox I,McNamara SG,Collins FL,et al."Syndrome Z": the interaction of sleep apnoea,vascular risk factors and heart disease.Thorax,1998,53:S25-S28.
8.	He J,Kryger MH,Zorick FJ,et al.Mortality and apnea index in obstructive sleep apnea.Experience in 385 male patients.Chest,1988,94:9-14.
9.	Ayas NT,White DP,Manson JE,et al.A prospective study of sleep duration and coronary heart disease in women.Arch Intern Med,2003;163:205-209.
10.	Haas DC,Foster GL,Nieto FJ,et al.Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study.Circulation,2005,111:614-621.
11.	Gami AS,Hodge DO,Herges RM,et al.Obstructive sleep apnea,obesity,and the risk of incident atrial fibrillation.J Am Coll Cardiol,2007,49:565-571.
12.	Lavie P,Lavie L,Herer P.All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age.Eur Respir J,2005,25:514-520.
13.	Somers VK,Dyken ME,Mark AL,et al.Sympathetic-nerve activity during sleep in normal subjects.N Engl J Med,1993;328:303-307.
14.	Somers VK,Mark AL,Zavala DC,et al.Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans.J Appl Physiol,1989,67:2095-2100.
15.	Narkiewicz K,van de Borne PJ,Cooley RL,et al.Sympathetic activity in obese subjects with and without obstructive sleep apnea.Circulation,1998,98:772-776.
16.	Copie X,Hnatkova K,Staunton A,et al.Predictive power of increased heart rate versus depressed left ventricular ejection fraction and heart rate variability for risk stratification after myocardial infarction.Results of a two-year follow-up study.J Am Coll Cardiol,1996,27:270-276.
17.	Phillips BG,Narkiewicz K,Pesek CA,et al.Effects of obstructive sleep apnea on endothelin-1 and blood pressure.J Hypertens,1999,17:61-66.
18.	Svatikova A,Wolk R,Shamsuzzaman AS,et al.Serum amyloid a in obstructive sleep apnea..Circulation,2003,108:1451-1454.
19.	Shamsuzzaman AS,Winnicki M,Lanfranchi P,et al.Elevated C-reactive protein in patients with obstructive sleep apnea.Circulation,2002,105:2462-2464.
20.	.Quan SF,Howard BV,Iber C,et al.The Sleep Heart Health Study: design,rationale,and methods.Sleep,1997,20:1077-1085.

1. Young T,Evans L,Finn L,et al.Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women.Sleep,1997,20:705-706.
2. Bixler EO,Vgontzas AN,Ten Have T,et al.Effects of age on sleep apnea in men: I.Prevalence and severity.Am J Respir Crit Care Med,1998,157:144-148.
3. Hu FB,Willett WC,Manson JE,et al.Snoring and risk of cardiovascular disease in women. J Am Coll Cardiol,2000,35:308-313.
4. Nieto FJ,Young TB,Lind BK,et al.Association of sleep-disordered breathing,sleep apnea,and hypertension in a large community-based study.Sleep Heart Health Study.JAMA,2000,283:1829-1836.
5. Elmasry A,Lindberg E,Berne C,et al.Sleep-disordered breathing and glucose metabolism in hypertensive men: a population-based study.J Intern Med,2001,249:153-161.
6. Hu FB,Willett WC,Colditz GA,et al.Prospective study of snoring and risk of hypertension in women.Am J Epidemiol,1999,150:806-816.
7. Wilcox I,McNamara SG,Collins FL,et al."Syndrome Z": the interaction of sleep apnoea,vascular risk factors and heart disease.Thorax,1998,53:S25-S28.
8. He J,Kryger MH,Zorick FJ,et al.Mortality and apnea index in obstructive sleep apnea.Experience in 385 male patients.Chest,1988,94:9-14.
9. Ayas NT,White DP,Manson JE,et al.A prospective study of sleep duration and coronary heart disease in women.Arch Intern Med,2003;163:205-209.
10. Haas DC,Foster GL,Nieto FJ,et al.Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study.Circulation,2005,111:614-621.
11. Gami AS,Hodge DO,Herges RM,et al.Obstructive sleep apnea,obesity,and the risk of incident atrial fibrillation.J Am Coll Cardiol,2007,49:565-571.
12. Lavie P,Lavie L,Herer P.All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age.Eur Respir J,2005,25:514-520.
13. Somers VK,Dyken ME,Mark AL,et al.Sympathetic-nerve activity during sleep in normal subjects.N Engl J Med,1993;328:303-307.
14. Somers VK,Mark AL,Zavala DC,et al.Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans.J Appl Physiol,1989,67:2095-2100.
15. Narkiewicz K,van de Borne PJ,Cooley RL,et al.Sympathetic activity in obese subjects with and without obstructive sleep apnea.Circulation,1998,98:772-776.
16. Copie X,Hnatkova K,Staunton A,et al.Predictive power of increased heart rate versus depressed left ventricular ejection fraction and heart rate variability for risk stratification after myocardial infarction.Results of a two-year follow-up study.J Am Coll Cardiol,1996,27:270-276.
17. Phillips BG,Narkiewicz K,Pesek CA,et al.Effects of obstructive sleep apnea on endothelin-1 and blood pressure.J Hypertens,1999,17:61-66.
18. Svatikova A,Wolk R,Shamsuzzaman AS,et al.Serum amyloid a in obstructive sleep apnea..Circulation,2003,108:1451-1454.
19. Shamsuzzaman AS,Winnicki M,Lanfranchi P,et al.Elevated C-reactive protein in patients with obstructive sleep apnea.Circulation,2002,105:2462-2464.
20. .Quan SF,Howard BV,Iber C,et al.The Sleep Heart Health Study: design,rationale,and methods.Sleep,1997,20:1077-1085.

Chinese Journal of Respiratory and Critical Care Medicine

Sleep Breathing Disorder，Coronary Heart Disease and Cardiac Arrtythmia

Abstract Full text Figures/Tables Video References Cited by

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