The relation between the human beta defensin-2 and systemic inflammatory responses in patients with the lower respiratory tract infection._Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LIU Song , HE Lirong , HE Zhengyi , WANG Haoyan

Department of Respiratory Diseases，Beijing Friendship Hospital，Capital Medical University. Beijing，100050，ChinaCorresponding Author: LIU Song. E-mail: liusongyy@yahoo.com.cn;

Corresponding author：

Keywords：

Human beta defensin-2 Lower respiratory tract infection; Inflammation; Interleukin

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Objective To investigate the relations between the human beta defensin-2 (HBD-2) and systemic inflammatory responses in patients with lower respiratory tract infection（LRTI）. Methods Eighty-one patients with confirmed LRTI including community-acquired pneumonia，acute exacerbation of chronic obstructive pulmonary disease or concurrent lung infection，and bronchiectasis concurrent infection were enrolled，and twenty healthy volunteers were included as control. Plasma concentrations of HBD-2，IL-1β，and IL-8 were assayed with ELISA method in all patients and controls. Furthermore the patients were divided into three groups according to the onset of disease:,ie.group A （shorter than 7 days），group B （7 to 14 days），and group C （more than 14 days）. The differences between these groups were compared. Correlation between HBD-2 and IL-1β or IL-8 concentrations was analyzed. Results HBD-2，IL-1β，white blood cell （WBC） of the peripheral blood in the patients with LRTI were all significantly higher than those in the healthy controls. HBD-2 and IL-1β increased in group A and group B，and decreased in group C comparing to the control group （P lt;0.05 respectively）. There was no significant difference of IL-8 in group A，B and C. HBD-2 showed a positive linear correlation with IL-1β （r=0.313，P=0.030） and no correlation with IL-8（P gt;0.05）. Conclusions The plasma HBD-2 concentration is increased in LRTI patients，which may be a biomarker of systemic inflammation in the early or relative early course of LRTI.

Citation： LIU Song,HE Lirong,HE Zhengyi,WANG Haoyan. The relation between the human beta defensin-2 and systemic inflammatory responses in patients with the lower respiratory tract infection.. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 12-14. doi: Copy

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1. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol，2003,3:710-720.
2. Pazgier M，Hoover DM，Yang D，et al. Human beta-defensins. Cell Mol Life Sci，2006，63: 1294-1313.
3. Tsutsumi-Ishii Y，Nagaoka I. Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J Immunol.2003,170: 4226-4236.
4. Dauletbaev N ，Gropp R，Frye M，et al. Expression of human beta defensin （HBD-1 and HBD-2） mRNA in nasal epithelia of adult cystic fibrosis patients，healthy individuals，and individuals with acute cold. Respiration，2002，69: 46-51.
5. Wehkamp K，Schwichtenberg L,Schroder J M，et al. Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1. J Invest Dermatol，2006，126: 121-127.
6. 中华医学会呼吸病学分会﹒社区获得性肺炎诊断和治疗指南﹒中华结核和呼吸杂志，2006，29：651-655.
7. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组﹒慢性阻塞性肺疾病诊治指南﹒中华结核和呼吸杂志，2007，30：7-16﹒.
8. 程德云﹒支气管扩张﹒见：朱元珏，陈文彬，主编﹒呼吸病学﹒第1版﹒北京：人民卫生出版社，2003年，892-901﹒.
9. Woodhead M，Blasi F，Ewig S,et al. Guidelines for the management of adult lower respiratory tract infections. Eur Respir J，2005; 26: 1138-1180.
10. Yang D,Biragya A，Hoover DM，et al. Multiple roles of antimicrobial defensins，cathelicidins，and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol，2004，22: 181-215.
11. Ashitani J，Mukae H，Arimura Y，et al. High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Life Sci. 2004; 75: 1123-34.

Chinese Journal of Respiratory and Critical Care Medicine

The relation between the human beta defensin-2 and systemic inflammatory responses in patients with the lower respiratory tract infection.

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