Tracheobronchopathia Osteochondroplastica: Two Cases Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

YE Jun ¹ , TAN Xiaoming ¹ , XIA Chunyan ¹ , SHI Zhaoquan ¹ , XIU Qingyu. ²

Department of Respiratory Disease,Changzheng Hospital, Second Military Medical University. Shanghai, 200003, ChinaCorresponding Author: SHI Zhao-quan, E-mail: ZSHI2005@ yahoo. com. cn;

Corresponding author：

Keywords：

Tracheobronchopathia osteochondroplastica; Diagnosis; Bronchoscopy; Computed tomography

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Objective To investigate the manifestations, diagnosis and treatment of tracheobronchopathia osteochondroplastica ( TO) . Methods Two cases of TO were described and 76 cases in the medical literature after 2000 were reviewed. Results TO usually manifests in adults, and affects both genders. The clinical presentation of TO is nonspecific. Bronchoscopy remains the gold standard for diagnosing this condition. Hard sessile nodules arising from the anterior and lateral walls of the airway,
typically sparing the posterior membrane, are classic appearance that can be easily recognized. The CT scan is more sensitive and specific, which plays an important role in the diagnosis of TO. Bronchial biopsies disclose the abnormal presence of cartilage and bone tissue in the bronchial submucosa. To date there is no
specific treatment for the disease. Only a minority of cases develop into significant upper airway obstruction and require invasive procedures to remove or bypass the obstacle on affected airways. Conclusions TO is a stable or slowly progressive benign disease. Chest computed tomography and fiberoptic bronchoscopy are the
best diagnostic procedures to identify TO.

Citation： YE Jun,TAN Xiaoming,XIA Chunyan,SHI Zhaoquan,XIU Qingyu.. Tracheobronchopathia Osteochondroplastica: Two Cases Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 66-69. doi: Copy

1.	陈建英,张心范,刘涛.骨化性气管支气管病误诊为支气管内膜结核.临床误诊误治,2002,15:177.
2.	罗红,周锐,郑东元.骨化性气管支气管病4例分析.中国现代医学杂志,2003,13:107-108.
3.	王珊娟,张马忠,杭燕南,等.弥漫性气管骨化一例.中华麻醉学杂志,2004,24:104.
4.	李海峰,邓毅书,冷静.骨化性气管支气管病1例报告.中华医学全科杂志,2004,3:46-48.
5.	金旭如,陈成水,李玉萍,等.骨化性气管支气管病3例临床分析.浙江医学,2005,27:223-225.
6.	龚建化,马经平,张家洪,等.骨化性气管支气管病1例报告.中国医师进修杂志-内科版,2006,29:73.
7.	张伟,赵怡卓,韩宝惠,等.骨化性气管支气管病二例报道及文献复习.上海医学,2006,29:772-774.
8.	王庞,项轶,高蓓莉,等.骨化性气管支气管病1例.诊断学:理论与实践,2007,6:61-62.
9.	王慧红,林云,冯加喜,等.骨化性气管支气管病1例.实用医学杂志,2007,23:3298.
10.	李慧梅,刘怡芝.骨化性气管支气管病1例及文献复习.中国医师进修杂志,2007,30（10）:74-75.
11.	徐虹,李伟峰,黄文杰.骨化性气管支气管病1例.广东医学,2008,29:398.
12.	Matsuba T, Komori M, Matsunaga R,et al. A case of tracheobronchopathia osteochondroplastica diagnosed by fiberoptic bronchoscopy upon removal of an aspirated crown. Diagn Ther Endosc.2001,7:63-67.
13.	Leske V, Lazor R, Coetmeur D,et al.Tracheobronchopathia osteochondroplastica: a study of 41 patients.Medicine (Baltimore),2001,80:378-390.
14.	Hussain K, Gilbert S.Tracheopathia osteochondroplastica.Clin Med Res,2003,1:239-242.
15.	Barthwal MS, Chatterji RS, Mehta A.Tracheobronchopathia osteochondroplastica.Indian J Chest Dis Allied Sci,2004,46:43-46..
16.	Kart L, Kiraz K, Büyüko?lan H, et al .Tracheobronchopathia osteochondroplastica: two cases and review of literature.Tuberk Toraks,2004,52:268-271.
17.	Simsek PO,Ozcelik U,Demirkazik F,et al.Tracheobronchopathia osteochondroplastica in a 9-year-old girl.Pediatr Pulmonol,2006,41:95-97.
18.	Tadjeddein A,Khorgami Z,Akhlaghi H.Tracheobronchopathia osteoplastica: cause of difficult tracheal intubation.Ann Thorac Surg,2006,81:1480-1482.
19.	Willms H,Wiechmann V,Sack U,et al.Tracheobronchopathia osteochondroplastica: A rare cause of chronic cough with haemoptysis.Cough,2008,4:4.
20.	Jabbardarjani HR, Radpey B, Kharabian S, et al.Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature.Lung,2008,186:293-297.
21.	Moura E Sa J, Almeida J, Amado J, et al.Tracheobronchopathia osteochondroplastica Experience of a Bronchology Unit.Rev Port Pneumol,2003,4:329-40.
22.	Tajima K,Yamakawa M,Katagiri T,et al.Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica.Virchows Arch,1997,431:359-363.
23.	Abu-Hijleh M, Lee D, Braman SS.Tracheobronchopathia osteochondroplastica: a rare large airway disorder.Lung,2008,186:353-359.

1. 陈建英,张心范,刘涛.骨化性气管支气管病误诊为支气管内膜结核.临床误诊误治,2002,15:177.
2. 罗红,周锐,郑东元.骨化性气管支气管病4例分析.中国现代医学杂志,2003,13:107-108.
3. 王珊娟,张马忠,杭燕南,等.弥漫性气管骨化一例.中华麻醉学杂志,2004,24:104.
4. 李海峰,邓毅书,冷静.骨化性气管支气管病1例报告.中华医学全科杂志,2004,3:46-48.
5. 金旭如,陈成水,李玉萍,等.骨化性气管支气管病3例临床分析.浙江医学,2005,27:223-225.
6. 龚建化,马经平,张家洪,等.骨化性气管支气管病1例报告.中国医师进修杂志-内科版,2006,29:73.
7. 张伟,赵怡卓,韩宝惠,等.骨化性气管支气管病二例报道及文献复习.上海医学,2006,29:772-774.
8. 王庞,项轶,高蓓莉,等.骨化性气管支气管病1例.诊断学:理论与实践,2007,6:61-62.
9. 王慧红,林云,冯加喜,等.骨化性气管支气管病1例.实用医学杂志,2007,23:3298.
10. 李慧梅,刘怡芝.骨化性气管支气管病1例及文献复习.中国医师进修杂志,2007,30（10）:74-75.
11. 徐虹,李伟峰,黄文杰.骨化性气管支气管病1例.广东医学,2008,29:398.
12. Matsuba T, Komori M, Matsunaga R,et al. A case of tracheobronchopathia osteochondroplastica diagnosed by fiberoptic bronchoscopy upon removal of an aspirated crown. Diagn Ther Endosc.2001,7:63-67.
13. Leske V, Lazor R, Coetmeur D,et al.Tracheobronchopathia osteochondroplastica: a study of 41 patients.Medicine (Baltimore),2001,80:378-390.
14. Hussain K, Gilbert S.Tracheopathia osteochondroplastica.Clin Med Res,2003,1:239-242.
15. Barthwal MS, Chatterji RS, Mehta A.Tracheobronchopathia osteochondroplastica.Indian J Chest Dis Allied Sci,2004,46:43-46..
16. Kart L, Kiraz K, Büyüko?lan H, et al .Tracheobronchopathia osteochondroplastica: two cases and review of literature.Tuberk Toraks,2004,52:268-271.
17. Simsek PO,Ozcelik U,Demirkazik F,et al.Tracheobronchopathia osteochondroplastica in a 9-year-old girl.Pediatr Pulmonol,2006,41:95-97.
18. Tadjeddein A,Khorgami Z,Akhlaghi H.Tracheobronchopathia osteoplastica: cause of difficult tracheal intubation.Ann Thorac Surg,2006,81:1480-1482.
19. Willms H,Wiechmann V,Sack U,et al.Tracheobronchopathia osteochondroplastica: A rare cause of chronic cough with haemoptysis.Cough,2008,4:4.
20. Jabbardarjani HR, Radpey B, Kharabian S, et al.Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature.Lung,2008,186:293-297.
21. Moura E Sa J, Almeida J, Amado J, et al.Tracheobronchopathia osteochondroplastica Experience of a Bronchology Unit.Rev Port Pneumol,2003,4:329-40.
22. Tajima K,Yamakawa M,Katagiri T,et al.Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica.Virchows Arch,1997,431:359-363.
23. Abu-Hijleh M, Lee D, Braman SS.Tracheobronchopathia osteochondroplastica: a rare large airway disorder.Lung,2008,186:353-359.

Chinese Journal of Respiratory and Critical Care Medicine

Tracheobronchopathia Osteochondroplastica: Two Cases Report and Literature Review

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