Three Cases of Primary Pulmonary Lymphoma and Review of the Literature_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHU Yanping , LI Xiangyang , ZHU Huili , QU Jieming

Department of Respiratory Medicine, Huadong Hospital, Fudan University. Shanghai, 200040, ChinaCorresponding Author: QU Jie-ming, E-mail: jmqu64@ yahoo. com. cn;

Corresponding author：

Keywords：

Primary pulmonary lymphoma; Diagnosis; Treatment

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Objective To study the clinical characteristics, diagnosis and treatment of primary pulmonary lymphoma. Methods A retrospective review of primary pulmonary lymphoma cases at a single institution from 2006 to 2008 was performed, and relevant literature was reviewed. Results Primary pulmonary lymphoma is a rare disease. The diagnosis was difficult because of the lack of specific characteristics. The most common symptoms were cough and fever. X-ray feature included solitary or multiple nodules and consolidation. Definite diagnosis was made by pathologic and immunohistchemical examinations. The recommended first-line therapy is chemotherapy. Conclusion Appropriate invasive biopsy is necessary for early diagnosis of primary pulmonary lymphoma

Citation： ZHU Yanping,LI Xiangyang,ZHU Huili,QU Jieming. Three Cases of Primary Pulmonary Lymphoma and Review of the Literature. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 70-72. doi: Copy

1.	Cordier JF,Chailleux E,Lauque D,et al.Primary pulmonary lymphomas.A clinical study of 70 cases in nonimmunocompromised patients.Chest,1993,103:201-208.
2.	Freeman C,Berg JW,Cutler SJ.Occurrence and prognosis of extranodal lymphomas.Cancer,1972,29:252-260.
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4.	Nicholson AG,Wotherspoon AC,Diss TC,et al.Reactive pulmonary lymphoid disorders.Histopathology,1995,26:405-412.
5.	Chow WH,Ducheine Y,Hilfer J,et al.Chronic pneumonia.Primary malignant non-Hodgkin’s lymphoma of the lung arising in mucosa-associated lymphoid tissue.Chest,1996,110:838-840.
6.	Bertoni F,Zucca E.Delving deeper into MALT lymphoma biology.J Clin Invest,2006,116:22-26.
7.	赵倩,赵绍宏,蔡祖龙,等.原发性肺淋巴瘤的CT表现.中国医学影像学杂志,2009,17:42-45.
8.	Zompi S,Couderc LJ,Cadranel J,et al.Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma.Blood,2004,103:3208-3215.
9.	Troch M,Streubel B,Petkov V,et al.Does MALT lymphoma of the lung require immediate treatment? An analysis of 11 untreated cases with long-term follow-up.Anticancer Res,2007,27:3633-3637.
10.	Conconi A,Martinelli G,Thiéblemont C,et al.Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type.Blood,2003,102:2741-2745.
11.	Raderer M,Jäger G,Brugger S,et al.Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma.Oncology,2003,65:306-310.

1. Cordier JF,Chailleux E,Lauque D,et al.Primary pulmonary lymphomas.A clinical study of 70 cases in nonimmunocompromised patients.Chest,1993,103:201-208.
2. Freeman C,Berg JW,Cutler SJ.Occurrence and prognosis of extranodal lymphomas.Cancer,1972,29:252-260.
3. Zinzani PL,Martelli M,Poletti V,et al.Practice guidelines for the management of extranodal non-Hodgkin’s lymphomas of adult non-immunodeficient patients.Part I: primary lung and mediastinal lymphomas.A project of the Italian Society of Hematology,the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation.Haematologica,2008,93:1364-1371.
4. Nicholson AG,Wotherspoon AC,Diss TC,et al.Reactive pulmonary lymphoid disorders.Histopathology,1995,26:405-412.
5. Chow WH,Ducheine Y,Hilfer J,et al.Chronic pneumonia.Primary malignant non-Hodgkin’s lymphoma of the lung arising in mucosa-associated lymphoid tissue.Chest,1996,110:838-840.
6. Bertoni F,Zucca E.Delving deeper into MALT lymphoma biology.J Clin Invest,2006,116:22-26.
7. 赵倩,赵绍宏,蔡祖龙,等.原发性肺淋巴瘤的CT表现.中国医学影像学杂志,2009,17:42-45.
8. Zompi S,Couderc LJ,Cadranel J,et al.Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma.Blood,2004,103:3208-3215.
9. Troch M,Streubel B,Petkov V,et al.Does MALT lymphoma of the lung require immediate treatment? An analysis of 11 untreated cases with long-term follow-up.Anticancer Res,2007,27:3633-3637.
10. Conconi A,Martinelli G,Thiéblemont C,et al.Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type.Blood,2003,102:2741-2745.
11. Raderer M,Jäger G,Brugger S,et al.Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma.Oncology,2003,65:306-310.

Chinese Journal of Respiratory and Critical Care Medicine

Three Cases of Primary Pulmonary Lymphoma and Review of the Literature

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