Objective To investigate the clinical characteristics, short-term therapy outcome and survival in patients of lung cancer with different smoking status. Methods 3751 cases were enrolled and the differences in age, sex, pathological type, stage, treatment modality, efficiency and survival were compared according patients′smoking status. Results 1206 ( 32. 2% ) patients were never smokers and 2545 ( 67. 8% ) were smokers. 80. 3% male patients and 10. 5% female patients were smokers. Among never smoking lung cancer patients, proportion of female gender, adenocarcinoma, second primary neoplasm,advanced stages and non-operative treatment were high. In the smokers, much more COPD and pulmonary tuberculosis, squamous cancer and operative treatmentwere found. No statistical differences were detected in overall outcome and survival. Conclusions The clinical characters and treatmentmodalities of patients with lung cancer of different smoking status were significant different, but had the same survival. Patients’smoking status should be accountted into the diagnosis and treatment of lung cancer.
Citation：
FANG Meiyu,JIANG Chuming,ZHAO Yazhen,ZHENG Yabing,MA Shenglin.. Clinical Investigation of Lung Cancer in Never Smokers. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(2): 177-180. doi:
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- 1. Doll R, Hill AB. Smoking and Carcinoma of the Lung; preliminary report. Br Med J, 1950, 2 : 739-748.
- 2. Wakelee HA, Chang ET, Gomez SL, et al. Lung cancer incidence in never smokers. J Clin Oncol, 2007, 25: 472 -478.
- 3. 景霞, 许建英. 吸烟对大鼠气道上皮细胞基质金属蛋白酶9 表达的影响. 中国呼吸与危重监护杂志, 2009, 8: 220-223.
- 4. Sardari Nia P, Weyler J, Colpaert C, et al. Prognostic value of smoking status in operated non-small cell lung cancer. Lung Cancer,2005, 47: 351 -359.
- 5. Shriver SP, Bourdeau HA, Gubish CT, et al. Sex-specific expression of gastrin-realing peptide receptor-relationship to smoking history and risk of lung cancer. J Natl Cancer Inst, 2000 , 92: 24-33.
- 6. Van Rens MT, de la Rivière AB, Elbers HR, et al. Prognostic assessment of 2 , 361 patients who underwent pulmonary resection for non-small cell lung cancer, Stage I, II, and IIIA. Chest, 2000, 117 :374-379.
- 7. Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-smallcell lung cancer: results from a randomized, placebo-controlled,multicentre study ( Iressa Survival Evaluation in Lung Cancer ) .Lancet, 2005 , 366: 1527 -1537 .
- 8. Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med, 2005 ,353: 123-132 .
