可溶性髓样细胞触发性受体1 对感染性疾病的诊断价值_Chinese Journal of Respiratory and Critical Care Medicine

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杨朴强 , 顾勤 , 刘宁 , 虞竹溪

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Keywords：

可溶性髓样细胞触发性受体1; 感染; 诊断

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感染性疾病的发病率高, 给社会经济带来沉重负担, 感染性疾病的早期诊断和治疗对提高临床疗效和降低死亡率有重要意义。髓样细胞触发性受体1 ( triggering receptor-1
expressed on myeloid cells, TREM-1) 在炎症反应的发生发展过程中起着重要的作用。Bouchon 等[ 1] 在2000 年首先发现TREM-1 选择性表达于中性粒细胞、CD14 + 单核细胞膜表面。后来的研究发现TREM-1 也表达于上皮细胞、多核巨细胞、腹膜巨噬细胞、淋巴结巨噬细胞、肺泡巨噬细胞, 纤维肉瘤细胞膜表面[ 2-5] 。人的TREM-1 由胞外区、跨膜区、胞浆区共同组成, 跨膜区含有1 个带正电荷的赖氨酸残基, 它可与接头蛋白DAP12 跨膜区内的带负电荷的天冬氨酸相偶联, 并通过胞浆区中的免疫受体酪氨酸活化基序( ITAM) 来激活下游信号传导, 促进促炎因子的分泌[ 6] 。TREM-1 激发、放大炎症反应的同时促进抗炎因子的下调[ 1, 2, 7] 。‥‥‥

Citation： 杨朴强,顾勤,刘宁,虞竹溪. 可溶性髓样细胞触发性受体1 对感染性疾病的诊断价值. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(2): 213-215. doi: Copy

1.	Bouchon A, Dietrich J, Colonna M, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol, 2000, 164 : 4991-4995.
2.	Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001, 410 : 1103-1107.
3.	Colonna M, Facchetti F. TREM-1 ( triggering receptor expressed on myeloid cells) : a new player in acute inflammatory responses. J Infect Dis, 2003, 187: S397-S401 .
4.	Allcock RJ, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6 p21 . 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol, 2003, 33 :567 -577.
5.	Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol, 2005 , 174 :517 -524.
6.	Kelker MS, Foss TR, Peti W, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 ( TREM-1) at1 . 47 A. J Mol Biol, 2004, 342: 1237-1248.
7.	Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol, 2003 , 170: 3812-3818.
8.	Góomez-Pi a V, Soares-Schanoski A, Rodríguez-Rojas A, et al.Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol, 2007 ,179 : 4065 -4073 .
9.	Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. NEngl J Med, 2004, 350: 451 -8.
10.	Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Critical Care, 2008, 12: R6 .
11.	Horonenko G, Hoyt JC, Robbins RA, et al. Soluble Triggering Receptor Expressed on Myeloid Cell-1 Is Increased in Patients With Ventilator-Associated Pneumonia. Chest, 2007 , 132: 58-63 .
12.	Anand NJ, Zuick S, Klesney-Tait J, et al. Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest, 2009, 135 :641 -647.
13.	Tejera A, Santolaria F, Diez M, et al. Prognosis of community acquired pneumonia ( CAP) : Value of triggering receptor expressed on myeloid cells-1 ( TREM-1 ) and other mediators of the inflammatory response. Cytokine, 2007 , 38: 117-123.
14.	Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med, 2005, 31: 1495-1500 .
15.	Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J, 2006, 28 : 695-702.
16.	Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res, 2004, 2 : 181-187.
17.	Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble- urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care,.
18.	Jiyong J, Tiancha H, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009 , 35: 587-595.
19.	Bishara J, Hadari M, Shalita-Chesner Z, et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis,2007, 26: 647-650 .
20.	Determann RM, Weisfelt M, Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med, 2006 , 32: 1243-1247.
21.	Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology, 2007 ,12: 333-338 .
22.	HUANG LZ, SHI HZ, LIANG QL, et al. Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J( Engl) , 2008, 121: 1656 -1661 .
23.	Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells In inflammatory bowel disease. World J Gastroenterol, 2006, 12 : 3416 -3419.
24.	Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis, Crit Care Med, 2008, 36: 2048-2053.
25.	, 11: R38.

1. Bouchon A, Dietrich J, Colonna M, et al. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol, 2000, 164 : 4991-4995.
2. Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001, 410 : 1103-1107.
3. Colonna M, Facchetti F. TREM-1 ( triggering receptor expressed on myeloid cells) : a new player in acute inflammatory responses. J Infect Dis, 2003, 187: S397-S401 .
4. Allcock RJ, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6 p21 . 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol, 2003, 33 :567 -577.
5. Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol, 2005 , 174 :517 -524.
6. Kelker MS, Foss TR, Peti W, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 ( TREM-1) at1 . 47 A. J Mol Biol, 2004, 342: 1237-1248.
7. Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol, 2003 , 170: 3812-3818.
8. Góomez-Pi a V, Soares-Schanoski A, Rodríguez-Rojas A, et al.Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes. J Immunol, 2007 ,179 : 4065 -4073 .
9. Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. NEngl J Med, 2004, 350: 451 -8.
10. Huh JW, Lim CM, Koh Y, et al. Diagnostic utility of the soluble triggering receptor expressed on myeloid cells-1 in bronchoalveolar lavage fluid from patients with bilateral lung infiltrates. Critical Care, 2008, 12: R6 .
11. Horonenko G, Hoyt JC, Robbins RA, et al. Soluble Triggering Receptor Expressed on Myeloid Cell-1 Is Increased in Patients With Ventilator-Associated Pneumonia. Chest, 2007 , 132: 58-63 .
12. Anand NJ, Zuick S, Klesney-Tait J, et al. Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest, 2009, 135 :641 -647.
13. Tejera A, Santolaria F, Diez M, et al. Prognosis of community acquired pneumonia ( CAP) : Value of triggering receptor expressed on myeloid cells-1 ( TREM-1 ) and other mediators of the inflammatory response. Cytokine, 2007 , 38: 117-123.
14. Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med, 2005, 31: 1495-1500 .
15. Phua J, Koay ES, Zhang D, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J, 2006, 28 : 695-702.
16. Gibot S, Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res, 2004, 2 : 181-187.
17. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble- urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care,.
18. Jiyong J, Tiancha H, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009 , 35: 587-595.
19. Bishara J, Hadari M, Shalita-Chesner Z, et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis,2007, 26: 647-650 .
20. Determann RM, Weisfelt M, Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Intensive Care Med, 2006 , 32: 1243-1247.
21. Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule ( triggering receptor expressed on myeloid cells-1) in the diagnosis of pleural effusion. Respirology, 2007 ,12: 333-338 .
22. HUANG LZ, SHI HZ, LIANG QL, et al. Expression of soluble triggering receptor expression on myeloid cells-1 in pleural effusion. Chin Med J( Engl) , 2008, 121: 1656 -1661 .
23. Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, et al. Role of soluble triggering receptor expressed on myeloid cells In inflammatory bowel disease. World J Gastroenterol, 2006, 12 : 3416 -3419.
24. Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis, Crit Care Med, 2008, 36: 2048-2053.
25. , 11: R38.

Chinese Journal of Respiratory and Critical Care Medicine

可溶性髓样细胞触发性受体1 对感染性疾病的诊断价值

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