Whether or Not Use High Does Inhaled Corticosteroids for Chronic Obstructive Pulmonary Disease_Chinese Journal of Respiratory and Critical Care Medicine

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WANG CHangzheng

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Keywords：

稳定期; COPD; 联合治疗; 吸入; 激素

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COPD 被定义为一种慢性肺部“炎症”性疾病。COPD 的炎症反应由吸烟、大气污染等有害颗粒或气体所诱发, 主要累及小气道和肺实质, 导致慢性支气管炎和气道阻塞; 同时还导致肺实质的破坏, 引起肺气肿, 形成不完全可逆的气流受限。COPD 的炎症以中性粒细胞为主, 肺泡巨噬细胞、CD8 + T细胞以及肥大细胞、嗜酸粒细胞、CD4 + T细胞和B 细胞等都可能参与了COPD 炎症过程。
糖皮质激素( 简称激素) 具有广泛的抗炎作用, 是临床最常用的抗炎药物。激素用于哮喘治疗取得了良好的临床疗效。但是在COPD 治疗上却存在许多争议．．．．．．

Citation： WANG CHangzheng. Whether or Not Use High Does Inhaled Corticosteroids for Chronic Obstructive Pulmonary Disease. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 228-229. doi: Copy

1.	Sahn SA. Corticosteroids in chronic bronchitis and pulmonary emphysema.Chest. 1978 Mar;73(3):389-96.
2.	van Grunsven PM, van Schayck CP, Derenne JP, et al.Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis. Thorax. 1999 Jan;54(1):7-14.
3.	Vestbo J, Sørensen T, Lange P, et al. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial.Lancet. 1999;353(9167):1819-23.
4.	Pauwels RA, Löfdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease.N Engl J Med. 1999 ;340(25):1948-53.
5.	The Lung Health Study Research Group.Effect of Inhaled Triamcinolone on the Decline in Pulmonary Function in Chronic Obstructive Pulmonary Disease. N Engl J Med 2000;343: 1902–1909.
6.	Burge PS, Calverley PM, Jones PW et al.Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ. 2000 ;13;320(7245):1297-303.
7.	Hattotuwa KL, Gizycki MJ, Ansari TW, et al.The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am J Respir Crit Care Med. 2002;165(12):1592-6.
8.	Culpitt SV, Maziak W, Loukidis S, et al.Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease.Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1635-9.
9.	Calverley P, Pauwels R, Vestboet J , et al.Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003, 361: 449–56.
10.	Calverley PM, Anderson JA, Celli B,et al, Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease. N Engl J Med 2007;356:775-89.
11.	Celli BR, Thomas NE, Anderson JA, et al. Effect of Pharmacotherapy on Rate of Decline of Lung Function in Chronic Obstructive Pulmonary Disease.Results from the TORCH Study. Am J Respir Crit Care Med. 2008 Aug 15;178(4):332-8.
12.	Barnes NC, Qiu YS, Pavord ID, et al .Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease.Am J Respir Crit Care Med. 2006 Apr 1;173(7):736-43.
13.	Bourbeau J, Christodoulopoulos P, Maltais F, et al..Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial. Thorax. 2007;62(11):938-43.
14.	Perng DW, Tao CW, Su KC, et al. Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD. Eur Respir J. 2009;33(4):778-84.
15.	Cazzola M, Di Lorenzo G, Di Perna F, et al.Additive effects of salmeterol and fluticasone or theophylline in COPD.Chest. 2000 Dec;118(6):1576-81.
16.	Tashkin DP, Rennard SI, Martin P, et al.. Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial. Drugs. 2008;68(14):1975-2000.
17.	Szafranski W, Cukier A, Ramirez A, et al.Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J. 2003;21(1):74-81.
18.	Hanania NA, Darken P, Horstman D, et al. The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD.Chest. 2003 Sep;124(3):834-43.
19.	Mortaz E, Rad MV, Johnson M, et al.Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke.J Mol Med. 2008 ;86(9):1045-56.
20.	Sarir H, Mortaz E, Karimi K, et al.Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages.Eur J Pharmacol. 2007;571(1):55-61.
21.	Mortaz E, Rad MV, Johnson M, et al.Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke. J Mol Med. 2008 September; 86(9): 1045–1056.

1. Sahn SA. Corticosteroids in chronic bronchitis and pulmonary emphysema.Chest. 1978 Mar;73(3):389-96.
2. van Grunsven PM, van Schayck CP, Derenne JP, et al.Long term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis. Thorax. 1999 Jan;54(1):7-14.
3. Vestbo J, Sørensen T, Lange P, et al. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial.Lancet. 1999;353(9167):1819-23.
4. Pauwels RA, Löfdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease.N Engl J Med. 1999 ;340(25):1948-53.
5. The Lung Health Study Research Group.Effect of Inhaled Triamcinolone on the Decline in Pulmonary Function in Chronic Obstructive Pulmonary Disease. N Engl J Med 2000;343: 1902–1909.
6. Burge PS, Calverley PM, Jones PW et al.Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ. 2000 ;13;320(7245):1297-303.
7. Hattotuwa KL, Gizycki MJ, Ansari TW, et al.The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am J Respir Crit Care Med. 2002;165(12):1592-6.
8. Culpitt SV, Maziak W, Loukidis S, et al.Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease.Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1635-9.
9. Calverley P, Pauwels R, Vestboet J , et al.Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003, 361: 449–56.
10. Calverley PM, Anderson JA, Celli B,et al, Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease. N Engl J Med 2007;356:775-89.
11. Celli BR, Thomas NE, Anderson JA, et al. Effect of Pharmacotherapy on Rate of Decline of Lung Function in Chronic Obstructive Pulmonary Disease.Results from the TORCH Study. Am J Respir Crit Care Med. 2008 Aug 15;178(4):332-8.
12. Barnes NC, Qiu YS, Pavord ID, et al .Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease.Am J Respir Crit Care Med. 2006 Apr 1;173(7):736-43.
13. Bourbeau J, Christodoulopoulos P, Maltais F, et al..Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial. Thorax. 2007;62(11):938-43.
14. Perng DW, Tao CW, Su KC, et al. Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD. Eur Respir J. 2009;33(4):778-84.
15. Cazzola M, Di Lorenzo G, Di Perna F, et al.Additive effects of salmeterol and fluticasone or theophylline in COPD.Chest. 2000 Dec;118(6):1576-81.
16. Tashkin DP, Rennard SI, Martin P, et al.. Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial. Drugs. 2008;68(14):1975-2000.
17. Szafranski W, Cukier A, Ramirez A, et al.Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J. 2003;21(1):74-81.
18. Hanania NA, Darken P, Horstman D, et al. The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD.Chest. 2003 Sep;124(3):834-43.
19. Mortaz E, Rad MV, Johnson M, et al.Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke.J Mol Med. 2008 ;86(9):1045-56.
20. Sarir H, Mortaz E, Karimi K, et al.Combination of fluticasone propionate and salmeterol potentiates the suppression of cigarette smoke-induced IL-8 production by macrophages.Eur J Pharmacol. 2007;571(1):55-61.
21. Mortaz E, Rad MV, Johnson M, et al.Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke. J Mol Med. 2008 September; 86(9): 1045–1056.

Chinese Journal of Respiratory and Critical Care Medicine

Whether or Not Use High Does Inhaled Corticosteroids for Chronic Obstructive Pulmonary Disease

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