Clinical Analysis of 34 Patients with Severe H1N1 Influenza_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZENG Weizhong , LI Shunwu , ZHOU Yuan , PENGSuna , ZHANG Xi.

Intensive Care Unit, Zhuzhou No.1 Hospital. Zhuzhou, Hunan, 412000, ChinaCorresponding Author: ZENGWei-zhong, E-mail: zengweizhong2@ yahoo. com. cn;

Corresponding author：

Keywords：

Severe H1N1 influenza; Oseltamivir; Mechanical ventilation

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Objective To analyze the clinical features and treatment of severe H1N1 influenza.Methods The clinical data of 34 patients with severe H1N1 influenza admitted to intensive care unit from October to December 2009 were reviewed. Results The patients aged 3 months to 60 years with an average of ( 13. 9 ±4. 5) years, of which 24 patients were younger than 7 years old. Fever( 30 cases) , cough( 32 cases) , progressive shortness of breath( 19 cases) were the main symptoms. White blood cell count was normal in 21 cases, increased in 6 cases, and decreased in 7 cases. Lymphocyte count was normal in 16 cases, increased in 12 cases, and decreased in6 cases. Chest X-ray films showed bilateral or unilateral patchy pulmonary fuzzy shadows in28 cases. Chest CT showed diffuse interstitial lesion in1 case, pleural effusion in 2 cases, and bronchiectasis in 1 case. The hepatic and myocardial enzymogramparameters were all abnormal.30 cases were treated by oseltamivir and ribavirin, 4 cases by methyllprednisolone, and 6 cases by gamma globulin. 8 cases underwent routine intubation and mechanical ventilation, and 5 cases received non-invasive mechanical ventilation. All 34 patients were cured. Conclusions Lung, heart, and liver are the major target organs in severe H1N1 influenza. Mechanical ventilatory support is an important treatment for severe H1N1
influenza.

Citation： ZENG Weizhong,LI Shunwu,ZHOU Yuan,PENGSuna,ZHANG Xi.. Clinical Analysis of 34 Patients with Severe H1N1 Influenza. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 230-233. doi: Copy

1.	Adiego Sancho B, Omenaca Teres M, Martinez Cuenca S, et al.Human case of swine influenza A ( H1N1 ) , Aragon, Spain,November 2008. Euro Surveill, 2009, 14: 19120 .
2.	卫生部甲型H1N1 流感诊疗方案( 2009 年试行版第三版) . 北京. 2009.
3.	冯旰珠, 周锋, 黄茂, 等. 热毒宁对流感病毒FM1 的抑制作用. 中国新药与临床杂志, 2007, 26 : 663-667.
4.	Centers for Disease Control and Prevention ( CDC) . 2009 pandemic influenza A ( H1N1 ) virus infections - Chicago, Illinois, April-July 2009. Morb Mortal Wkly Rep, 2009 , 58: 913-918.
5.	Jain S, Kamimoto L, Bramley AM, et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med, 2009, 361 : 1935 -1944.
6.	李冠华, 张力, 李月川, 等. 重症甲型H1N1 流感病毒肺炎的临床和病理特征. 天津医药, 2010, 38: 32-35.
7.	Kobasa D, Takuda A, Shinga K, et al. Enhanced virulence of influenza A Viruses with the haemag glutinin of the 1918 Pandemic Virus. Nature, 2004, 431: 703-707.
8.	Jung T, Choi C, Chae C. Localization of swine influenza virus in naturally infected pigs. Vet Pathol, 2002, 39 : 10-16.
9.	Cao B, Li XW,MAO Y, et al. Clinical features of the initial cases of 2009 pandemic influenza A( H1N1 ) virus infection in china. N Engl J Med, 2009, 361 , 2507 -2517.
10.	姚蓉, 刘亚玲, 陈斌, 等. 四川省135 例重症甲型H1N1 流感病例的临床分析. 中国呼吸与危重监护杂志, 2010 , 9, 7-11.
11.	WHO guidelines for pharmacological managoment of pandemic ( H1N1 ) 2009 influenza and other influenza virues, Geneva: World Health organization, August 20, 2009.

1. Adiego Sancho B, Omenaca Teres M, Martinez Cuenca S, et al.Human case of swine influenza A ( H1N1 ) , Aragon, Spain,November 2008. Euro Surveill, 2009, 14: 19120 .
2. 卫生部甲型H1N1 流感诊疗方案( 2009 年试行版第三版) . 北京. 2009.
3. 冯旰珠, 周锋, 黄茂, 等. 热毒宁对流感病毒FM1 的抑制作用. 中国新药与临床杂志, 2007, 26 : 663-667.
4. Centers for Disease Control and Prevention ( CDC) . 2009 pandemic influenza A ( H1N1 ) virus infections - Chicago, Illinois, April-July 2009. Morb Mortal Wkly Rep, 2009 , 58: 913-918.
5. Jain S, Kamimoto L, Bramley AM, et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med, 2009, 361 : 1935 -1944.
6. 李冠华, 张力, 李月川, 等. 重症甲型H1N1 流感病毒肺炎的临床和病理特征. 天津医药, 2010, 38: 32-35.
7. Kobasa D, Takuda A, Shinga K, et al. Enhanced virulence of influenza A Viruses with the haemag glutinin of the 1918 Pandemic Virus. Nature, 2004, 431: 703-707.
8. Jung T, Choi C, Chae C. Localization of swine influenza virus in naturally infected pigs. Vet Pathol, 2002, 39 : 10-16.
9. Cao B, Li XW,MAO Y, et al. Clinical features of the initial cases of 2009 pandemic influenza A( H1N1 ) virus infection in china. N Engl J Med, 2009, 361 , 2507 -2517.
10. 姚蓉, 刘亚玲, 陈斌, 等. 四川省135 例重症甲型H1N1 流感病例的临床分析. 中国呼吸与危重监护杂志, 2010 , 9, 7-11.
11. WHO guidelines for pharmacological managoment of pandemic ( H1N1 ) 2009 influenza and other influenza virues, Geneva: World Health organization, August 20, 2009.

Chinese Journal of Respiratory and Critical Care Medicine

Clinical Analysis of 34 Patients with Severe H1N1 Influenza

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