Viral Etiology of Acute Lower Respiratory Infection in Adult Inpatients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHOU Yiping ¹ , LU Xuedong ² , CHEN Xiaoke ¹ , YANG Laizhi ² , LIU Hui ¹ , YU Haiqiong. ¹

Department of Respiratory Medicine, Shenzhen Futian Hospital Affiliated to Guangdong Medical College. Shenzhen, Guangdong,518033, ChinaCorresponding Author: ZHOU Yi-ping, E-mail: zhouypft@ yahoo. com. cn;

Corresponding author：

Keywords：

Lower respiratory tract infection; Viruses; Etiology

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Objective To investigate the viral etiology of acute lower respiratory tract infection in adult inpatients. Methods 192 adult inpatients suffering from community-acquired pneumonia, acute bronchitis, or acute exacerbation of chronic obstructive pulmonary disease, admitted from October 2007 to October 2008, were enrolled in the study. Swabs from the nasopharynxes were collected. Multiple polymerase chain reaction was employed to identify the 7 common species of respiratory virus ( including 11
subspecies) . Serumspecific IgM against several viruses were detected by indirect immunofluorescence. 106 healthy volunteers were enrolled as control. Results Only 4 cases were found to be infected with virus in 106 healthy volunteers. Viruses were identified in 80 ( 41. 6% ) cases of 192 inpatients and 99 ( 51. 5% )viral strains were detected. The most common viruses identified in the inpatients were influenza virus A ( FluA) , rhinovirus ( RhV) , and parainfluenza virus 1 ( PIV1) . The ratio of the 3 virus strains to the all strains identified was 81. 8% ( 81/99) . Serumspecific IgM was positive in 61 ( 31. 7% ) inpatients and 73 ( 38. 0% ) viral strains were detected. The most common viruses identified in the inpatients were FluA, PIV1,and respiratory syncytial virus ( RSV) . When summing up the data from the swabs and serum, 91 ( 47. 3% )
cases had viral infection in 192 inpatients and 110 ( 57. 2% ) viral strains were detected. Conclusion The rate of viral infection is relatively high in the adult inpatients with acute lower respiratory tract infection, and the most common species are FluA, RhV, and PIV1.

Citation： ZHOU Yiping,LU Xuedong,CHEN Xiaoke,YANG Laizhi,LIU Hui,YU Haiqiong.. Viral Etiology of Acute Lower Respiratory Infection in Adult Inpatients. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(4): 378-382. doi: Copy

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12.	徐军, 郭静霞, 李浩, 等. 不明原因呼吸道感染疫情病原学分析.解放军医学杂志, 2010, 35: 252 -255.
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14.	耿素珍. 间接免疫荧光法对多种呼吸道病毒快速检测方法. 包头医学院学报, 2008, 24: 477-478 .
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1. Creer DD, Dilworth JP, Gillespie SH, et al. Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection ( LRTI) in primary care. Thorax, 2006, 61: 75 -79 .
2. Johnstone J, Majumdar SR, Fox JD, et al. Viral infection in adults hospitalized with community-acquired pneumonia: prevalence,pathogens, and presentation. Chest, 2008, 134: 1141-1148.
3. Marcos AM, Camps M, Pumarola T, et al. The role of viruses in the aetiology of community acquired pneumoniain adults. Antivir Ther,2006, 11: 351-359.
4. 中华医学会呼吸病学分会. 社区获得性肺炎诊断和治疗指南.中华结核和呼吸杂志, 2006, 29: 651 -655.
5. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南. 中华结核和呼吸杂志, 2007, 30 : 8-17 .
6. 陆学东, 林广裕, 周仁彬, 等. 广东地区首例人博卡病毒的检出及鉴定. 中华传染病杂志, 2008, 26: 614 -616.
7. 周一平, 陆学东, 陈小可, 等. 急性下呼吸道感染患者支气管肺泡灌洗掖非典型病原体与病毒检测. 中华医院感染学杂志,2007, 17: 901-904 .
8. Jennings LC, Anderson TP, Beynon KA, et al. Incidence and characteristics of viral community-acquired pneumonia in adults.Thorax, 2008, 63 : 42-48.
9. 邓继岿, 罗宏英, 郑跃杰, 等. 深圳地区80 例儿童下呼吸道感染人类偏肺病毒的检测. 广东医学, 2006, 27: 1809-1810.
10. 刘克洲, 陈智, 主编. 人类病毒性疾病. 北京: 人民卫生出版社,2002, 918.
11. Garbino J, Gerbase MW, Wunderli W, et al. Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact. Am J Respir Crit Care Med, 2004, 170 : 1197-1203.
12. 徐军, 郭静霞, 李浩, 等. 不明原因呼吸道感染疫情病原学分析.解放军医学杂志, 2010, 35: 252 -255.
13. Peng D, Zhao D, Liu J, et al. Multipathogen infections in hospitalized children with acute respiratory infections. Virol J, 2009 ,6: 155 .
14. 耿素珍. 间接免疫荧光法对多种呼吸道病毒快速检测方法. 包头医学院学报, 2008, 24: 477-478 .
15. McCullers JA. Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev, 2006 , 19: 571-582.

Chinese Journal of Respiratory and Critical Care Medicine

Viral Etiology of Acute Lower Respiratory Infection in Adult Inpatients

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