上气道咳嗽综合征与慢性咽喉炎的诊断问题_Chinese Journal of Respiratory and Critical Care Medicine

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赖克方

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上气道咳嗽综合征; 慢性咽喉炎; 诊断

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2006 年美国胸科医师学会( ACCP) 咳嗽指南委员会修订的第二版美国咳嗽诊治指南建议用上气道咳嗽综合征( upper airway cough syndrome, UACS) 替代鼻后滴流综合征( post nasal drip syndrome, PNDS) [1] 。PNDS 最早由美国提出, 指鼻炎或鼻窦炎引起分泌物倒流鼻后和咽喉等部位, 导致以咳嗽为主要表现的综合征[2] 。欧美国家和国内研究表明, UACS 或PNDS 是慢性咳嗽的重要原因, 国内的数据为14% ～26% [3-6] 。总体而言, 欧美国家PNDS 的患病率更高,占慢性咳嗽病因的12% ～41% [7-9] 。

Citation： 赖克方. 上气道咳嗽综合征与慢性咽喉炎的诊断问题. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(5): 454-455. doi: Copy

1.	Pratter MR. Overview of common causes of chronic cough: ACCP evidence-based clinical practice guidelines. Chest, 2006 , 129 :59S-62S.
2.	Irwin RS, Boule LP, Cloutier MM, et al. Managing cough as a defense mechanism and as a symptom. Chest,1998, 114: 133S-181S.
3.	赖克方, 陈如冲, 刘春丽, 等. 慢性咳嗽的病因分布及诊断程序探讨. 中华结核和呼吸杂志, 2006 , 29: 96-99 .
4.	马洪明, 朱礼星, 赖克方, 等. 不明原因慢性咳嗽的诊断探讨. 中华内科杂志, 2003 , 26: 675 -678.
5.	王志虹, 林江涛, 李勇, 等. 慢性咳嗽的病因诊断及治疗效果. 中国医学科学院学报, 2007, 29 : 665-668.
6.	杨忠民, 邱忠民, 吕寒静. 慢性咳嗽病因的前瞻性研究. 同济大学学报( 医学版) , 2005 , 26: 62-64.
7.	Irwin RS, Curley FJ, Frech CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation,and outcome of specific therapy. Am Rev Respir Dis, 1990, 141 :640-647.
8.	Palombini BC, Villanova AC, Araujo E, et al. A pathogenic triad in chronic cough: Asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest, 1999, 116: 279 -284.
9.	Brightling CE, Ward R, Goh KL, et al. Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med,1999, 160: 406-410.
10.	Morice AH, Fontana GA, Sovijarvi AR, et al. The diagnosis and management of chronic cough. Eur Respir J, 2004, 24 : 481-492.
11.	中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南( 2009 版) . 中华结核和呼吸杂志, 2009, 32 : 407-413 .
12.	张巧, 马千里, 黄赞胜, 等. 上气道咳嗽综合征病因的初步研究.中国呼吸与危重监护杂志, 2010, 9: 458 -461.
13.	陈如冲, 赖克方, 许丹媛, 等. 伴有咽喉炎样表现的慢性咳嗽的病因分布. 中国呼吸与危重监护杂志, 2010, 9 : 462-464.
14.	赖克方, 陈如冲, 林玲, 等. 不同慢性咳嗽病因的咳嗽特征及伴随症状的诊断价值探讨. 中华结核和呼吸杂志, 2009, 32: 418-421.
15.	Irwin RS, Zawacki JK. Accurately diagnosing and successfully treating chronic cough due to gastroesophageal reflux disease can be difficult. Am J Gastroenterol, 1999, 94: 3095-3098.

1. Pratter MR. Overview of common causes of chronic cough: ACCP evidence-based clinical practice guidelines. Chest, 2006 , 129 :59S-62S.
2. Irwin RS, Boule LP, Cloutier MM, et al. Managing cough as a defense mechanism and as a symptom. Chest,1998, 114: 133S-181S.
3. 赖克方, 陈如冲, 刘春丽, 等. 慢性咳嗽的病因分布及诊断程序探讨. 中华结核和呼吸杂志, 2006 , 29: 96-99 .
4. 马洪明, 朱礼星, 赖克方, 等. 不明原因慢性咳嗽的诊断探讨. 中华内科杂志, 2003 , 26: 675 -678.
5. 王志虹, 林江涛, 李勇, 等. 慢性咳嗽的病因诊断及治疗效果. 中国医学科学院学报, 2007, 29 : 665-668.
6. 杨忠民, 邱忠民, 吕寒静. 慢性咳嗽病因的前瞻性研究. 同济大学学报( 医学版) , 2005 , 26: 62-64.
7. Irwin RS, Curley FJ, Frech CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation,and outcome of specific therapy. Am Rev Respir Dis, 1990, 141 :640-647.
8. Palombini BC, Villanova AC, Araujo E, et al. A pathogenic triad in chronic cough: Asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest, 1999, 116: 279 -284.
9. Brightling CE, Ward R, Goh KL, et al. Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med,1999, 160: 406-410.
10. Morice AH, Fontana GA, Sovijarvi AR, et al. The diagnosis and management of chronic cough. Eur Respir J, 2004, 24 : 481-492.
11. 中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南( 2009 版) . 中华结核和呼吸杂志, 2009, 32 : 407-413 .
12. 张巧, 马千里, 黄赞胜, 等. 上气道咳嗽综合征病因的初步研究.中国呼吸与危重监护杂志, 2010, 9: 458 -461.
13. 陈如冲, 赖克方, 许丹媛, 等. 伴有咽喉炎样表现的慢性咳嗽的病因分布. 中国呼吸与危重监护杂志, 2010, 9 : 462-464.
14. 赖克方, 陈如冲, 林玲, 等. 不同慢性咳嗽病因的咳嗽特征及伴随症状的诊断价值探讨. 中华结核和呼吸杂志, 2009, 32: 418-421.
15. Irwin RS, Zawacki JK. Accurately diagnosing and successfully treating chronic cough due to gastroesophageal reflux disease can be difficult. Am J Gastroenterol, 1999, 94: 3095-3098.

Chinese Journal of Respiratory and Critical Care Medicine

上气道咳嗽综合征与慢性咽喉炎的诊断问题

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