A Preliminary Study on Etiology of Upper Airway Cough Syndrome_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHANG Qiao ¹ , MA Qianli ¹ , HUANG Zansheng ¹ , CHENG Xiaoming ¹ , CAO Guoqiang ² , WANG Changzheng. ¹

Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University. Chongqing, 400037, ChinaCorresponding Author: WANG Chang-zheng, E-mail: czwang@ netease. com;

Corresponding author：

Keywords：

Chronic cough; Upper airway cough syndrome; Cough variant asthma; Gastroesophageal reflux

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Objective To investigate the clinical characteristics of upper airway cough syndrome ( UACS) and the relationship of UACS with upper airway diseases, cough variant asthma ( CVA) , and gastroesophageal reflux disease ( GERD) . Methods 92 subjects with chronic cough and throat symptoms and signs were included in the study. The medical records were collected fromall subjects, and 49 subjects suspected for CVA undertook bronchial provocation test. Then the efficacy was evaluated and etiology were analyzed based on the efficacy of targeted treatment. Results Bronchial provocation test yielded positive results in 14 subjects suspected of CVA, accounting for 15. 2% of all cases ( 14/92) . 18. 5% ( 17 /92) of patients had a history of chronic gastritis or combined symptoms of GERD, of whom anti-gastroesophageal
reflux treatment was effective. The patients with rhinitis, sinusitis history and/ or symptoms accounted for 33. 7% of cases ( 31 cases) . 51. 1% ( 47/92) of patients had only signs and symptoms of chronic pharyngitis. Conclusions UACS is not only due to the rhinitis and/ or sinusitis but also chronic pharyngitis. Chronic pharyngitis may be secondary to chronic rhinitis/ sinusitis with post nasal drip and gastroesophageal reflux, also may be an independent cause of chronic cough.

Citation： ZHANG Qiao,MA Qianli,HUANG Zansheng,CHENG Xiaoming,CAO Guoqiang,WANG Changzheng.. A Preliminary Study on Etiology of Upper Airway Cough Syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(5): 458-461. doi: Copy

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8.	韩德民, 张罗, 黄丹, 等. 我国11 个城市变应性鼻炎自报患病率调查. 中华耳鼻喉头颈部外科杂志. 2007; 42 : 378-384.
9.	王建亭, 石宝玉. 表现为慢性咽喉炎的胃食管反流病21 例临床分析. 山西医科大学学报, 2009, 40: 524-525.
10.	贾晓东, 朱优立. 反流性咽喉炎的临床分析. 中华实用诊断与治疗杂志, 2009, 23 : 93 -94.
11.	Pavord ID, Chung KF.Management of chronic cough. Lancet, 2008,371: 1375-1384.
12.	Pratter MR, Bartter T, Akers S, et al. An algorithmic approach to chronic cough. Ann Intern Med, 1993, 119: 977 -983.
13.	Bolser DC. Older-generation antihistamines and cough due to upper airway cough syndrome ( UACS) : efficacy and mechanism. Lung,2008, 186: S74-S77 .

1. 赖克方, 陈如冲, 刘春丽, 等. 不明原因慢性咳嗽的病因分布及诊断程序的建立. 中华结核和呼吸杂志, 2006, 29 : 96-99.
2. 王志虹, 林江涛, 李勇, 等. 慢性咳嗽的病因诊断及治疗效果.中国医学科学院学报, 2007, 29: 665-668 .
3. 曹国强, 程晓明, 戴晓天, 等. 重庆地区慢性咳嗽病因的多中心研究, 中国呼吸与危重监护杂志, 2009 , 8: 565-568 .
4. Morice AH, Fontana GA, Sovijarvi AR, et al. The diagnosis and management of chronic cough, Eur Respir J, 2004, 24: 481-492.
5. Pratter MR. Chronic upper airway cough syndrome secondary to rhinosinus diseases ( previously referred to as postnasal drip syndrome) : ACCP evidence-based clinical practice guidelines.Chest, 2006, 129: 63S-71S.
6. Morice AH, McGarvey L, Pavord I. Recommendations for the management of cough in adults. Thorax, 2006 , 61 : i1-i24.
7. Klossek JM, Annesi-Maesano I, Pribil C, et al. INSTANT: national survey of allergic rhinitis in a French adult population basedsample.Presse Med, 2009, 38: 1220-1229.
8. 韩德民, 张罗, 黄丹, 等. 我国11 个城市变应性鼻炎自报患病率调查. 中华耳鼻喉头颈部外科杂志. 2007; 42 : 378-384.
9. 王建亭, 石宝玉. 表现为慢性咽喉炎的胃食管反流病21 例临床分析. 山西医科大学学报, 2009, 40: 524-525.
10. 贾晓东, 朱优立. 反流性咽喉炎的临床分析. 中华实用诊断与治疗杂志, 2009, 23 : 93 -94.
11. Pavord ID, Chung KF.Management of chronic cough. Lancet, 2008,371: 1375-1384.
12. Pratter MR, Bartter T, Akers S, et al. An algorithmic approach to chronic cough. Ann Intern Med, 1993, 119: 977 -983.
13. Bolser DC. Older-generation antihistamines and cough due to upper airway cough syndrome ( UACS) : efficacy and mechanism. Lung,2008, 186: S74-S77 .

Chinese Journal of Respiratory and Critical Care Medicine

A Preliminary Study on Etiology of Upper Airway Cough Syndrome

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