The Role of theComplement Receptor 1 and 3 on Neutrophils in Distinguishing Bacterial Infection in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

DONG Zhaoxing , YU Guohui , CHAI Yanling , LI Qihao , ZHANG Tao

Department of Respiratory Medicine, Second Affiliated Hospital of Kunming Medical College. Kunming, Yunnan, 650101, ChinaCorresponding Author: ZHANG Tao, E-mail: zt6958@ sina. com;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Bacterial infection; Complement receptor 1 on neutrophils; Complement receptor 3 on neutrophils

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Objective To study the role of the complement receptor 1 and 3 ( CR1 and CR3) on neutrophils in distinguishing bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease ( AECOPD) . Methods 40 patients with AECOPD were divided into two groups according to the detection of bacteria in subairway. 20 patients with stable COPD and 20 healthy subjects with no history of smoking were also included. According to Anthonisen criteria, 40 AECOPD patients were
divided into type Ⅰ( 11 cases) , type Ⅱ ( 12 cases) , and type Ⅲ( 17 cases) . The levels of CR1 and CR3 in blood were measured by flow cytometry. Results In AECOPD patients, 25 cases were detected bacteria,and 15 cases were not detected bacteria. The level of CR1 and CR3 were highest in the bacterial infection group than other groups, and highest in type Ⅰ AECOPD patients than other types. ROC analysis showed that CR1 and CR3 had good diagnostic value in bacterial infection in AECOPD, with optimal cutoff values of 11 and 52, respectively. Conclusion CR1 and CR3 may be good index of distinguishing bacterial infection in AECOPD.

Citation： DONG Zhaoxing,YU Guohui,CHAI Yanling,LI Qihao,ZHANG Tao. The Role of theComplement Receptor 1 and 3 on Neutrophils in Distinguishing Bacterial Infection in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(5): 481-484. doi: Copy

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7.	Elghetany MT. Surface antigen changes during normal neutrophilic development: a critical review. Blood Cells Mol Dis, 2002, 28: 260 -274.
8.	Krych M, Hauhart R, Atkinson JP. Structure-function analysis of the active sites of complement receptor type 1 . J Biol Chem, 1998, 273 :8623-8629.
9.	Etzioni A. Adhesion molecules———their role in health and disease.Pediatr Res, 1996 , 39: 191 -198.
10.	Cohen JH, Atkinson JP, Klickstein LB, et al. The C3b /C4 b receptor ( CR1, CD35 ) on erythrocytes: methods for study of the polymorphisms. Mol Immunol, 1999, 36: 819-825 .
11.	Nuutila J, Hohenthal U, Laitinen I, et al. Quantitative analysis of complement receptors, CR1 ( CD35 ) and CR3 ( CD11b ) , on neutrophils improves distinction between bacterial and viral infections in febrile patients: comparison with standard clinical laboratory data. J Immunol Methods, 2006, 315: 191 -201.
12.	Soler N, Agusti C, Angrill J, et al. Validation of Anthonisen criteria in infectious COPD exacerbation among patients requiring hospitalization. Eur Respir J, 2004, 24: 411s.

1. Lindenauer PK, Pekow P, Gao S, et al. Quality of care for patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease. Ann Intern Med, 2006, 144 : 894-903.
2. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南( 2007 年修订版) . 中华结核和呼吸杂志,2007, 30: 8-17.
3. Pavord ID, Pizzichini MM, Pizzichini E, et al. The use of induced sputumto investigate airway inflammation. Thorax.1997, 52: 498-501.
4. Anthonisen NR, Manfreda J,Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med, 1987, 106: 196 -204.
5. Simon L, Gauvin F, Amre DK, et al. Serum procalcitonin and Creactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis, 2004, 39: 206 -217.
6. Polzin A, Pletz M, Erbes R, et al. Procalcitonin as a diagnostic tool in lower respiratory tract infections and tuberculosis. Eur Respir J,2003, 21: 939-943 .
7. Elghetany MT. Surface antigen changes during normal neutrophilic development: a critical review. Blood Cells Mol Dis, 2002, 28: 260 -274.
8. Krych M, Hauhart R, Atkinson JP. Structure-function analysis of the active sites of complement receptor type 1 . J Biol Chem, 1998, 273 :8623-8629.
9. Etzioni A. Adhesion molecules———their role in health and disease.Pediatr Res, 1996 , 39: 191 -198.
10. Cohen JH, Atkinson JP, Klickstein LB, et al. The C3b /C4 b receptor ( CR1, CD35 ) on erythrocytes: methods for study of the polymorphisms. Mol Immunol, 1999, 36: 819-825 .
11. Nuutila J, Hohenthal U, Laitinen I, et al. Quantitative analysis of complement receptors, CR1 ( CD35 ) and CR3 ( CD11b ) , on neutrophils improves distinction between bacterial and viral infections in febrile patients: comparison with standard clinical laboratory data. J Immunol Methods, 2006, 315: 191 -201.
12. Soler N, Agusti C, Angrill J, et al. Validation of Anthonisen criteria in infectious COPD exacerbation among patients requiring hospitalization. Eur Respir J, 2004, 24: 411s.

Chinese Journal of Respiratory and Critical Care Medicine

The Role of theComplement Receptor 1 and 3 on Neutrophils in Distinguishing Bacterial Infection in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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