Differences in Biological Features Between Male and Female Patients with Obstructive Sleep Apnea Hypopnea Syndrome_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Liman ¹ , ZHOU Guangyao ¹ , LIU Yafeng ¹ , LI Chunhua ¹ , LEI Fei ² , TANG Xiangdong ² , LIANG Zongan ³

Department of Otolaryngology-Head Neck Surgery, West China Hospital,Sichuan University. Chengdu, Sichuan, 610041, ChinaCorresponding Author: ZHOU Guang-yao, E-mail: zhguangyao@ hotmail. com;

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Keywords：

Obstructive sleep apnea-hypopnea syndrome; Apnea; Hypopnea; Gender differences

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Objective To investigate the differences in biological features between male and female patients with obstructive sleep apnea-hypopnea syndrome( OSAHS) . Methods 192 cases of patients with snoring were analyzed in the Sleep Medicine Center of West ChinaHospital fromSeptember 2004 to February 2005. The standard sleep disorder questionnaires, neck circumference, hight, weight, and all night polysomnography ( PSG) were evaluated. The clinical features of the male and female patients with OSAHS were compared. Results 170 cases of patients met the criteria of OSAHS for the apnea-hypopnea index ( AHI) more than 5 times per hour. Male gender accounted for 90% of the total patients ( male vs. female 153 vs. 17, 9∶1) . The age of male patients with OSAHS was younger than that of female ( 45. 7 ±11. 4 years
vs. 58. 0 ±6. 1 years, P = 0. 000) . Parameters including neck circumference ( 37. 6 ±3. 2 cm vs. 35. 6 ±3. 2 cm, P =0. 000) , waist/hip rate ( 0. 94 ±0. 04 vs. 0. 9 ±0. 06, P = 0. 000) , AHI ( 36. 4 ±25. 7 vs.21. 4 ±17. 4, P =0. 004) , oxygen desaturation index ( 34. 5 ±27. 4 vs. 22. 2 ±20. 8, P =0. 035) , the number of smoking ( 52. 9% vs. 5. 9% , P = 0. 000) and drinking ( 46. 4% vs. 5. 9% , P = 0. 001) were different among the male and female patients with OSAHS. On the other hand, the morning headache ( 70. 6% vs.26. 1%, P = 0. 005) , mouth dry( 76. 5% vs. 47. 7% , P = 0. 025) , bad temper ( 52. 9% vs. 19. 0% , P =0. 004) , and hypertension ( 52. 9% vs. 20. 9% , P =0. 007) were more common in the female patients with OSAHS. Conclusion There are significant differences between male and female patients with OSAHS in prevalence, age, symptoms, and severity of the disease.

Citation： WANG Liman,ZHOU Guangyao,LIU Yafeng,LI Chunhua,LEI Fei,TANG Xiangdong,LIANG Zongan. Differences in Biological Features Between Male and Female Patients with Obstructive Sleep Apnea Hypopnea Syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(5): 501-503. doi: Copy

1.	Duran J, Esnaola S, Rubio R, et al. Obstructive sleep apneahypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. AmJ Respir Crit Care Med, 2001, 163 :685-689.
2.	Young T, Palta M, Dempsey J, et al. The occurrence of sleepdisordered breathing among middle-aged adults. N Engl J Med,1993, 328: 1230-1235.
3.	Young T. Analytic epidemiology studies of sleep disordered breathing: what explains the gender difference in sleep disordered breathing? Sleep, 1993 , 16: S1-S2 .
4.	中华医学会耳鼻咽喉科学分会. 阻塞性睡眠呼吸暂停低通气综合征诊断依据和疗效评定标准暨悬雍垂腭咽成形术适应证( 杭州) . 中华耳鼻咽喉科杂志, 2002, 37: 403-404 .
5.	Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleepdisordered breathing in women: effects of gender. Am J Respir Crit Care Med, 2001, 163 : 608-613.
6.	Whittle AT, Marshall I, Mortimore IL, et al. Neck soft tissue and fat distribution: comparison between normal man and women by magnetic rensonance imaging. Thorax, 1999, 54 : 323-328.
7.	Guilleminault C, Stoohs R, Kim YD, et al. Upper airway sleepdisordered breathing in women. Ann Intern Med, 1995,122: 493-501.
8.	Redline S, Kump K, Tishler PV, et al. Gender differences in sleep disordered breathing in a community-based sample. Am J Respir Crit Care Med, 1994, 149: 722-726.
9.	Popovic RM, White DP. Influence of gender on waking genioglossal electromyogram and upper airway resistance. Am J Respir Crit Care Med, 1995, 152: 725-731.
10.	Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol, 1998, 84 :1055-1062.
11.	Wetter DW, Young TB, Bidwell TR, et al. Smoking as a risk factor for sleep disordered breathing. Arch Intern Med, 1994, 154: 2219-2224.
12.	Rosen CL. Obstructive sleep apnea syndrome( OSAS) in children:diagnostic challenge. Sleep, 1996, 19: S274-S277 .
13.	李洁, 王翎. 老年睡眠呼吸暂停综合征的特点. 国际呼吸杂志,2008, 28: 357-359 .

1. Duran J, Esnaola S, Rubio R, et al. Obstructive sleep apneahypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. AmJ Respir Crit Care Med, 2001, 163 :685-689.
2. Young T, Palta M, Dempsey J, et al. The occurrence of sleepdisordered breathing among middle-aged adults. N Engl J Med,1993, 328: 1230-1235.
3. Young T. Analytic epidemiology studies of sleep disordered breathing: what explains the gender difference in sleep disordered breathing? Sleep, 1993 , 16: S1-S2 .
4. 中华医学会耳鼻咽喉科学分会. 阻塞性睡眠呼吸暂停低通气综合征诊断依据和疗效评定标准暨悬雍垂腭咽成形术适应证( 杭州) . 中华耳鼻咽喉科杂志, 2002, 37: 403-404 .
5. Bixler EO, Vgontzas AN, Lin HM, et al. Prevalence of sleepdisordered breathing in women: effects of gender. Am J Respir Crit Care Med, 2001, 163 : 608-613.
6. Whittle AT, Marshall I, Mortimore IL, et al. Neck soft tissue and fat distribution: comparison between normal man and women by magnetic rensonance imaging. Thorax, 1999, 54 : 323-328.
7. Guilleminault C, Stoohs R, Kim YD, et al. Upper airway sleepdisordered breathing in women. Ann Intern Med, 1995,122: 493-501.
8. Redline S, Kump K, Tishler PV, et al. Gender differences in sleep disordered breathing in a community-based sample. Am J Respir Crit Care Med, 1994, 149: 722-726.
9. Popovic RM, White DP. Influence of gender on waking genioglossal electromyogram and upper airway resistance. Am J Respir Crit Care Med, 1995, 152: 725-731.
10. Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol, 1998, 84 :1055-1062.
11. Wetter DW, Young TB, Bidwell TR, et al. Smoking as a risk factor for sleep disordered breathing. Arch Intern Med, 1994, 154: 2219-2224.
12. Rosen CL. Obstructive sleep apnea syndrome( OSAS) in children:diagnostic challenge. Sleep, 1996, 19: S274-S277 .
13. 李洁, 王翎. 老年睡眠呼吸暂停综合征的特点. 国际呼吸杂志,2008, 28: 357-359 .

Chinese Journal of Respiratory and Critical Care Medicine

Differences in Biological Features Between Male and Female Patients with Obstructive Sleep Apnea Hypopnea Syndrome

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