严重感染患者外周血中树突状细胞的变化及意义_Chinese Journal of Respiratory and Critical Care Medicine

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于晴 , 刘军 , 邱海波

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Keywords：

感染; 外周血; 树突状细胞

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严重感染及感染性休克是全身性感染( sepsis) 导致的以器官功能损害为特征的复杂临床综合征, 在ICU患者的发病率高达25% [1] 。近年来, 尽管抗感染治疗及器官功能支持
技术取得了长足的进步, 但严重感染的病死率仍高达30% ～70% [2] 。严重感染的发病机制复杂, 免疫功能的紊乱参与严重感染的发生与发展。树突状细胞( DCs) 在启动机体免疫应答中发挥关键性作用。近年研究显示, 严重感染患者外周血DCs 数量及功能呈现明显动态改变, 并与病情严重程度及预后相关。因此监测严重感染的危重病患者外周血DCs
改变具有重要的临床意义。

Citation： 于晴,刘军,邱海波. 严重感染患者外周血中树突状细胞的变化及意义. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(6): 647-648. doi: Copy

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3.	Kohrgruber N, Halanek N, Groger M, et al. Survival, maturation, and function of CD11c + and CD11c - peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol, 1999 , 163 :3250-3259.
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7.	Efron P, Moldawer LL. Sepsis and the dendritic cell. Shock, 2003 ,20: 386-401 .
8.	Zhang Z, Xu DP, Li YG, et al. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunol,2005, 116: 225-235.
9.	Poehlmann H, Schefold JC, Zuckermann-Becker H, et al. Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. Critical Care,2009, 13: 1-12.
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11.	Guisset O, Dilhuydy MS, Thiebaut R, et al. Decrease in circulating dendritic cells predicts fatal outcome in septic shock. Intensive Care Med, 2007, 33: 148-152 .
12.	Maier M, Geiger EV, Henrich D, et al. Apoptosis differs in dendritic cell subsets early after severe trauma. Human Immunol, 2009 , 70 :803-808.
13.	Hotchkiss RS, Tinsley KW, Swanson PE, et al. Depletion of dendritic cells, but not macrophages, in patients with Sepsis. J Immunol,2002, 168: 2493-2500.
14.	Efron PA, Martins A, Minnich D, et al. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol, 2004, 173: 3035-3043.
15.	Rescigno M, Granucci F, Ricciardi-Castagnoli P, et al. Dendritic cells at the end of the millennium. Immunol Cell Biolol, 1999, 77 :404-410.
16.	Caux C, Vanbervliet B, Massacrier, et al. Regulation of dendritic cell recruitment by chemokines. Transplantation, 2002, 73: S7-S11.
17.	Allavenal P, Piemonti1 L, Longoni D, et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol, 1998, 28: 359-369 .
18.	Faivre V, Lukaszewicz AC, Alves A, et al. Accelerated in vitro differentiation of blood monocytes into dendritic cells in human sepsis. Clin Exper Immunol, 2007 , 147: 426-439.
19.	D′Arpa N, Accardo-Palumbo A, Amato G, et al. Circulating dendritic cells following burn. Burns, 2009, 35: 513 -518.

1. Brun-Buisson C. The epidemiology of the systemic inflammatory response. Intensive Care Med, 2000 , 26: S64-S74 .
2. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from1979 through 2000. N Engl J Med, 2003 ,348 : 1546 -1554 .
3. Kohrgruber N, Halanek N, Groger M, et al. Survival, maturation, and function of CD11c + and CD11c - peripheral blood dendritic cells are differentially regulated by cytokines. J Immunol, 1999 , 163 :3250-3259.
4. Rissoan M, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science, 1999 , 283 :1183-1186.
5. Arpinati M, Green CL, Heimfeld S, et al. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells.Blood, 2000, 95: 2484-2490.
6. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol, 2000 , 18: 767-811.
7. Efron P, Moldawer LL. Sepsis and the dendritic cell. Shock, 2003 ,20: 386-401 .
8. Zhang Z, Xu DP, Li YG, et al. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Clinical Immunol,2005, 116: 225-235.
9. Poehlmann H, Schefold JC, Zuckermann-Becker H, et al. Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. Critical Care,2009, 13: 1-12.
10. Takahashi KJ, Satoi S, Yanagimoto H, et al. Circulating dendritic cells and development of septic complications after pancreatectomy for pancreatic cancer. Arch Surg, 2007, 142 : 1151 -1157 .
11. Guisset O, Dilhuydy MS, Thiebaut R, et al. Decrease in circulating dendritic cells predicts fatal outcome in septic shock. Intensive Care Med, 2007, 33: 148-152 .
12. Maier M, Geiger EV, Henrich D, et al. Apoptosis differs in dendritic cell subsets early after severe trauma. Human Immunol, 2009 , 70 :803-808.
13. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Depletion of dendritic cells, but not macrophages, in patients with Sepsis. J Immunol,2002, 168: 2493-2500.
14. Efron PA, Martins A, Minnich D, et al. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol, 2004, 173: 3035-3043.
15. Rescigno M, Granucci F, Ricciardi-Castagnoli P, et al. Dendritic cells at the end of the millennium. Immunol Cell Biolol, 1999, 77 :404-410.
16. Caux C, Vanbervliet B, Massacrier, et al. Regulation of dendritic cell recruitment by chemokines. Transplantation, 2002, 73: S7-S11.
17. Allavenal P, Piemonti1 L, Longoni D, et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol, 1998, 28: 359-369 .
18. Faivre V, Lukaszewicz AC, Alves A, et al. Accelerated in vitro differentiation of blood monocytes into dendritic cells in human sepsis. Clin Exper Immunol, 2007 , 147: 426-439.
19. D′Arpa N, Accardo-Palumbo A, Amato G, et al. Circulating dendritic cells following burn. Burns, 2009, 35: 513 -518.

Chinese Journal of Respiratory and Critical Care Medicine

严重感染患者外周血中树突状细胞的变化及意义

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