HU Hefang , SHI Hui , CHE Guowei , LUO Fengming
  • West China Hospital, Sichuan University. Chengdu, 61004, ChinaCorresponding Author: LUO Feng-ming, E-mail: luofengming@ hotmail. com;
Lung cancer; Jumonji domain-containing protein3; Tumor stages; Survival analysis
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective  To investigate the expression of Jumonji domain-containing protein 3 ( JMJD3) in lung cancer tissue. Methods  The cancer tissue slides from 53 lung cancer patients with different TNMstages were immunostained with JMJD3 antibody. The relationship between the expression of JMJD3 and type of pathology, TNM stage, survival time was analyzed. Results 94. 3% lung cancer tissue expressed JMJD3 protein. The expression of JMJD3 was negatively correlated with TNMstage( r = - 0. 347,P =0. 002) . The patients with decreased JMJD3 expression had shorter survival time than the patients with high JMJD3 expression ( X2 = 17. 83, P = 0. 001) . Conclusion  Decreased expression of JMJD3 may promote the lung cancer progression.

Citation： HU Hefang,SHI Hui,CHE Guowei,LUO Fengming. The Expression of Jumonji Domain-Containing Protein 3 in Lung Cancer Tissue. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(2): 168-170. doi: Copy