HONG Yongqing , ZHURong , MENG Zili.
  • Department of Pulmonary Medicine, First People’s Hospital of Huai’an, Affiliated Hospital of Nanjing Medical University. Huai’an, Jiangsu, 223300, ChinaCorresponding Author: HONG Yong-qing, E-mail: hy6388@ 163. com;
Mechanical ventilation; Fiberoptic bronchoscopy; Serious lung infection; Protected specimen brush; Bronchoalveolar lavage
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Objective  To compare the diagnostic value of sterile sputumsuction tube with protected specimen brush in mechanically ventilated patients with serious lung infection, and explore the safety and efficacy of bronchofibroscope combining mechanical ventilation in the treatment of severe lung infection.Methods  Seventy-four severe lung infection patients with invasive mechanical ventilation support were recruited in the study. Based on the routine treatment, the subjects were randomly divided into a control group received only mechanical ventilation, and a treatment group received sputum aspiration and bronchial lavage by bronchofibroscope combiningmechanical ventilation. Lower respiratory tract secretion was collected to analyze the bacterial etiology with sterile sputum suction tube in the control group, and with protected
specimen brush in the treatment group. Results  The positive rate of sputum suction tube and protected specimen brush was 70. 27% and 75. 68% , respectively, with no statistical difference between the two groups ( P  gt; 0. 05) . The PaO2 of the treatment group increased and PaCO2 decreased obviously after sputum aspiration and bronchial lavage by bronchofibroscope ( P  lt; 0. 01) . The total effective rate was also highly increased, and the heart rate and respiration were stable in the treatment group. The time of mechanical ventilation and the length of ICU stay were all shortened in the treatment group compared with the control group. Conclusions  Sterile sputum suction tube can not only acquire accurate pathogen, but also is a simple and economical method for patients with severe lung infection with mechanical ventilation. Sputum aspiration and bronchial lavage with bronchofibroscope combining mechanical ventilation are effective and safe treatment for patients with severe lung infection.

Citation： HONG Yongqing,ZHURong,MENG Zili.. Clinical Efficacy of Interventional Therapy with Fiberoptic Bronchoscopy in Patients with Severe Lung Infection with InvasiveMechanical VentilationSupport. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(3): 237-240. doi: Copy