LIU Haitao , HE Jingtang , TIAN Tao , LI Zhijuan , GUO Zhijun , YANG Jingwei , ZHANG Jihua , MA Yan , REN Jinjun
  • Department of Respiratory Medicine, General Hospital of Huabei Oilfield. Renqiu, Hebei,062552, China Corresponding Author: LIU Hai-tao, E-mail: huayouhuxineike@ 126. com;
Acute massive pulmonary thromboembolism; Reteplase; Ateplase; Thrombolysis
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Objective  To compare the efficacy of reteplase and ateplase in the treatment of acute massive pulmonary thromboembolism ( PTE) in emergency.
Methods  From January 2005 to December 2009,42 patients with acute massive PTE were treated by intravenous thrombolysis with reteplase or ateplase. The thrombolysis efficacy, bleeding incidence and mortality were measured.
Results  In the reteplase group, the emergency thrombolysis effective rate was 88. 9% among 18 patients. Mild bleeding occurred in 3 patients,moderate bleeding in 1 patient, and 2 cases died in hospital. In the ateplase group, the emergency thrombolysis effective rate was 75% among 24 patients. Mild bleeding occurred in 3 patients, moderate bleeding in 2 patients, and 3 cases died in hospital. The thrombolysis effective rate, bleeding incidence and mortality had no significant difference between the two groups.
Conclusion  Both the reteplase and ateplase thrombolysis therapy are safe and effective in the treatment of acute massive PTE, but reteplase thrombolysis therapy is more convenient in emergency.

Citation： LIU Haitao,HE Jingtang,TIAN Tao,LI Zhijuan,GUO Zhijun,YANG Jingwei,ZHANG Jihua,MA Yan,REN Jinjun. Efficacy of Reteplase and Ateplase in Treatment of Acute Massive Pulmonary Thromboembolism: A Comparative Study. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(3): 270-273. doi: Copy