Objective To investigate the effects of different levels of intra-abdominal pressure ( IAP) on respiration and hemodynamics in a porcine model of acute lung injury( ALI) .
Methods A total of 8 domestic swine received mechanical ventilation. Following baseline observations, oleic acid 0. 1mL/kg in 20mL of normal saline was infused via internal jugular vein. Using a nitrogen gas pneumoperitongum, the IAP increased from0 to 15 and 25mmHg, and the groups were named IAP0 , IAP15 and IAP25 , respectively. During the experimental period, hemodynamic parameters including heart rate ( HR) , cardiac output ( CO) , mean arterial pressure( MAP) , central venous pressure( CVP) , intrathoracic blood volume index( ITBVI) and so on were obtained by using thermodilution technique of pulse induced continuous cardiac output( PiCCO) . The esophageal pressure( Pes) was dynamicly monitored by the esophageal catheter.
Results Pes and peak airway pressure( Ppeak) increased and static lung compliance( Cstat) decreased significantly in IAP15 and IAP25 groups compared with IAP0 group( all P  lt;0. 01) . Transpulmonary pressure( Ptp) showed a downward trend( P  gt;0. 05) . PO2 and oxygenation index showed a downward trend while PCO2 showed a upward trend ( P  gt;0. 05) . HR and CVP increased significantly, cardiac index( CI) and ITBV index decreased significantly ( all P  lt;0. 05) ,MAP didn′t change significantly( P  gt;0. 05) . The changes in Pes were negatively correlated with the changes in CI( r = - 0. 648, P = 0. 01) .
Conclusion In the porcine model of ALI, Pes increases because of a rise in IAP which decreased pulmonary compliance and CI.

Citation： QI Hui,GU Qin,HANG Yunhong,XU Ying,LIU Ning,NIU Xiaorong.. Effects of High Intra-abdomianl Pressure on Respiration and Hemodynamics in A Porcine Model of Acute Lung Injury. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(6): 532-536. doi: Copy