Quality of Life after Video-assisted Thoracoscopic Surgery or Minimal Incision Thoracotomy for Early Stage Non small Cell Lung Cancer : A Prospective, Randomized Controlled Trial_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIN , SITU Dongrong , MA Guowei

1. Department of Thoracic Surgery，Cancer Center， Sun Yat-sen University， Guangzhou 510060，P. R. China;;
2. Lung Cancer Research Center，Sun Yat-sen University， Guangzhou 510060，P. R. China;;
3. State Key Laboratory of Oncology in South China，Guangzhou 510060，P. R. China;

Corresponding author：

Keywords：

Video-assisted thoracoscopic surgery; Minimal incision thoracotomy; Lung neoplasm; Quality of life Foundation item： Sun Yat-Sen University Clinical Research 5010 Program（2007039）

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Abstract： Objective To evaluate video-assisted thoracic surgery（VATS）and minimal incision thoracotomy（MIT）lobectomy for early stage non-small cell lung cancer patients and the impact upon postoperative quality of life（QOL）. Methods A prospective randomized controlled trial was conducted. From January 1, 2008 to December 10, 2011, the qualified patients with early stage NSCLC were recruited and randomized to VATS group （57 patients）and MIT group（49 patients）, totally 106 patients，57 males and 49 females, aged 57.60 years. The quality of life was assessed using Lung Cancer Symptom Scale （LCSS） before operation and at 1,3,6,9,12 months after operation. Results There were no significant differences between the 2 groups in age, sex, the location of tumor, tumor pathologic stage, pathological types, postoperative complications, tumor size, operative time, operative bleeding and air leak days. There were no symptoms after operation at the VATS group worse than the leve before operation. Five major symptoms, including appetit（1.04±0.71 vs.2.00±0.83, F=6.357，P=0.021）, fatigue （4.55±1.17 vs.10.19±2.10, F=4.721，P=0.043）, dyspnea（2.18±0.86 vs.10.26±2.05, F=10.020，P=0.005）, normal activity（5.16±1.70 vs.17.60±3.17, F=12.319，P=0.002）at the MIT group were deteriorated significantly at 1 month after the operation （P＜0.05）. Conclusion The VATS will lead to better quality of life for the patients with early stage NSCLC after surgery and lead to a smooth postoperative recovery.

Citation： LIN ,SITU Dongrong,MA Guowei,et al. Quality of Life after Video-assisted Thoracoscopic Surgery or Minimal Incision Thoracotomy for Early Stage Non small Cell Lung Cancer : A Prospective, Randomized Controlled Trial. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2012, 19(2): 130-135. doi: Copy

1.	?2 Nakamura H， Taniguchi Y， Miwa K， et al. Comparison of the surgical outcomes of thoracoscopic lobectomy， segmentectomy， and wedge resection for clinical stageⅠnon-small cell lung cancer. Thorac Cardiovasc Surg， 2011， 59（3）：137-141.
2.	?3 Hollen PJ， Gralla RJ， Rittenberg CN. Quality of life as a clinical.
3.	trial endpoint： determining the appropriate interval for repeated.
4.	assessments in patients with advanced lung cancer. Support Care Cancer， 2004， 12（11）：767-773.
5.	?4 Peterson DE， Bensadoun RJ， Lalla RV， et al. Supportive care treatment guidelines： value， limitations， and opportunities. Semin.
6.	Oncol， 2011， 38（3）：367-373.
7.	?5 Demmy TL， Nwogu C. Is video-assisted thoracic surgery lobectomy better? Quality of life considerations. Ann Thorac Surg， 2008， 85（2）：S719-728.
8.	?6 Alonso Y. The biopsychosocial model in medical research： the evolution of the health concept over the last two decades. Patient Educ Couns， 2004， 53（2）：239-244.
9.	?7 Donington JS， Koo CW， Ballas MS. Novel therapies for non-small cell lung cancer. J Thorac Imaging， 2011， 26（2）：175-185.
10.	?8 Keogh JW， Jones L. The importance of promoting physical activity for cancer survivorship. N Z Med J， 2011， 124（1337）：6-9.
11.	?9 Win T， Sharples L， Wells FC， et al. Effect of lung cancer surgery on quality of life. Thorax， 2005， 60（3）：234-238.
12.	Middleton J. Healthy people， healthy lives. The english public health white paper： risks and challenges for a new public health system. Clin Med， 2011， 11（5）：430-433.
13.	Balduyck B， Hendriks J， Sardari Nia P， et al. Quality of life after lung cancer surgery： a review. Minerva Chir， 2009， 64（6）：655-663.
14.	龙浩，林志潮，林勇斌，等. 早期非小细胞肺癌胸腔镜手术与小切口肺切除术后患者生活质量的对比研究 . 癌症，2007， 26（6）：624-628.
15.	龙浩，林志潮，林勇斌，等. 胸腔镜与小切口开胸肺切除术后生活质量的对比性研究. 中国微创外科杂志， 2008， 8（2）：137-142.
16.	龙浩，林志潮，司徒冬荣，等. 胸腔镜手术与小切口开胸肺切除术后细胞因子反应的随机对照临床研究. 癌症，2007， 26（9）：991-995.
17.	Balduyck B， Hendriks J， Lauwers P， et al. Quality of life evolution after lung cancer surgery： a prospective study in 100 patients. Lung Cancer， 2007， 56（3）：423-431.
18.	Aoki T， Tsuchida M， Hashimoto T， et al. Quality of life after lung cancer surgery： video-assisted thoracic surgery versus thoracotomy. Heart Lung Circ， 2007， 16（4）：285-289.
19.	Li WW， Lee TW， Lam SS， et al. Quality of life following lung cancer resection： video-assisted thoracic surgery vs thoracotomy. Chest， 2002， 122（2）：584-589.
20.	Gorenstein LA， Sonett JR . The surgical management of stageⅠ and stageⅡ lung cancer. Surg Oncol Clin N Am， 2011， 20（4）：.
21.	D’Amico TA. Operative techniques in early-stage lung cancer. J Natl Compr Canc Netw， 2010， 8（7）：807-813.
22.	Handy JR Jr， Asaph JW， Douville EC， et al. Does video-assisted thoracoscopic lobectomy for lung cancer provide improved functional outcomes compared with open lobectomy? Eur J Cardiothorac Surg， 2010， 37（2）：451-455.
23.	Hollen PJ， Gralla RJ， Kris MG， et al. A comparison of visual analogue and numerical rating scale formats for the Lung Cancer Symptom Scale （lcss）： does format affect patient ratings of symptoms and quality of life? Qual Life Res， 2005， 14（3）：837-847.
24.	-720.

1. ?2 Nakamura H， Taniguchi Y， Miwa K， et al. Comparison of the surgical outcomes of thoracoscopic lobectomy， segmentectomy， and wedge resection for clinical stageⅠnon-small cell lung cancer. Thorac Cardiovasc Surg， 2011， 59（3）：137-141.
2. ?3 Hollen PJ， Gralla RJ， Rittenberg CN. Quality of life as a clinical.
3. trial endpoint： determining the appropriate interval for repeated.
4. assessments in patients with advanced lung cancer. Support Care Cancer， 2004， 12（11）：767-773.
5. ?4 Peterson DE， Bensadoun RJ， Lalla RV， et al. Supportive care treatment guidelines： value， limitations， and opportunities. Semin.
6. Oncol， 2011， 38（3）：367-373.
7. ?5 Demmy TL， Nwogu C. Is video-assisted thoracic surgery lobectomy better? Quality of life considerations. Ann Thorac Surg， 2008， 85（2）：S719-728.
8. ?6 Alonso Y. The biopsychosocial model in medical research： the evolution of the health concept over the last two decades. Patient Educ Couns， 2004， 53（2）：239-244.
9. ?7 Donington JS， Koo CW， Ballas MS. Novel therapies for non-small cell lung cancer. J Thorac Imaging， 2011， 26（2）：175-185.
10. ?8 Keogh JW， Jones L. The importance of promoting physical activity for cancer survivorship. N Z Med J， 2011， 124（1337）：6-9.
11. ?9 Win T， Sharples L， Wells FC， et al. Effect of lung cancer surgery on quality of life. Thorax， 2005， 60（3）：234-238.
12. Middleton J. Healthy people， healthy lives. The english public health white paper： risks and challenges for a new public health system. Clin Med， 2011， 11（5）：430-433.
13. Balduyck B， Hendriks J， Sardari Nia P， et al. Quality of life after lung cancer surgery： a review. Minerva Chir， 2009， 64（6）：655-663.
14. 龙浩，林志潮，林勇斌，等. 早期非小细胞肺癌胸腔镜手术与小切口肺切除术后患者生活质量的对比研究 . 癌症，2007， 26（6）：624-628.
15. 龙浩，林志潮，林勇斌，等. 胸腔镜与小切口开胸肺切除术后生活质量的对比性研究. 中国微创外科杂志， 2008， 8（2）：137-142.
16. 龙浩，林志潮，司徒冬荣，等. 胸腔镜手术与小切口开胸肺切除术后细胞因子反应的随机对照临床研究. 癌症，2007， 26（9）：991-995.
17. Balduyck B， Hendriks J， Lauwers P， et al. Quality of life evolution after lung cancer surgery： a prospective study in 100 patients. Lung Cancer， 2007， 56（3）：423-431.
18. Aoki T， Tsuchida M， Hashimoto T， et al. Quality of life after lung cancer surgery： video-assisted thoracic surgery versus thoracotomy. Heart Lung Circ， 2007， 16（4）：285-289.
19. Li WW， Lee TW， Lam SS， et al. Quality of life following lung cancer resection： video-assisted thoracic surgery vs thoracotomy. Chest， 2002， 122（2）：584-589.
20. Gorenstein LA， Sonett JR . The surgical management of stageⅠ and stageⅡ lung cancer. Surg Oncol Clin N Am， 2011， 20（4）：.
21. D’Amico TA. Operative techniques in early-stage lung cancer. J Natl Compr Canc Netw， 2010， 8（7）：807-813.
22. Handy JR Jr， Asaph JW， Douville EC， et al. Does video-assisted thoracoscopic lobectomy for lung cancer provide improved functional outcomes compared with open lobectomy? Eur J Cardiothorac Surg， 2010， 37（2）：451-455.
23. Hollen PJ， Gralla RJ， Kris MG， et al. A comparison of visual analogue and numerical rating scale formats for the Lung Cancer Symptom Scale （lcss）： does format affect patient ratings of symptoms and quality of life? Qual Life Res， 2005， 14（3）：837-847.
24. -720.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Quality of Life after Video-assisted Thoracoscopic Surgery or Minimal Incision Thoracotomy for Early Stage Non small Cell Lung Cancer : A Prospective, Randomized Controlled Trial

Abstract Full text Figures/Tables Video References Cited by

Format

Content