Abstract: Sarcoidosis is a common systemic disease with noncaseating granulomatous epithelioid nodule and coexisting granulomatous inflammation. Although sarcoidosis can affect any organ of the body, more than 90% of the patients demonstrate thoracic involvement, which is often confusing with lung cancer and other diseases. Therefore, thoracic surgeons must have a clear understanding of sarcoidosis. Moreover, due to the special role of surgery in obtaining pathological specimens, thoracic surgeon plays an important role in the diagnosis and treatment of sarcoidosis. It is not difficult to make diagnosis for patients with typical clinical features of sarcoidosis. However, the majority of patients do not have specific manifestations of sarcoidosis. The cause of sarcoidosis remains unknown, and there is also no specific treatment strategy for it. But recent research has shown that annexin A11 gene may be involved in the pathogenesis of sarcoidosis, and tumor necrosis factor (TNF) inhibitor is effective in the treatwent of sarcoidosis.
Citation: YANG Heli,CHEN Keneng.. Sarcoidosis-A Disease Needs to Be Differentiated from Lung Cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2012, 19(6): 663-667. doi: Copy
1. | Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med, 2007, 357 (21):2153-2165. |
2. | Tremblay A, Stather DR, Maceachern P, et al. A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis. Chest, 2009, 136 (2): 340-346. |
3. | 赵辉, 王俊, 李剑锋, 等. 纵隔镜检查在胸部结节病诊断中的价值. 中华医学杂志, 2005, 85 (13): 919-921. |
4. | Dempsey OJ, Paterson EW, Kerr KM, et al. Sarcoidosis. BMJ, 2009, 339 (7721): 620-625. |
5. | Balan A, Hoey ET, Sheerin F, et al. Multi-technique imaging of sarcoidosis. Clin Radiol, 2010, 65 (9):750-760. |
6. | Park HJ, Jung Jl, Chung MH, et al. Typical and atypical manifestations of intrathoracic sarcoidosis. Korean J Radiol, 2009, 10 (6): 623-631. |
7. | Criado E, Sanche Z, Ramiez J, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation. Radiographics, 2010, 30 (6): 1567-1586. |
8. | Fisher KA, Serlin DM, Wilson KC, et al. Sarcoidosis-associated pulmonary hypertension: outcome with long-term epoprostenol treatment. Chest, 2006, 130 (5): 1481-1488. |
9. | Bonfioli AA, Orefice F. Sarcoidosis. Semin Ophthalmol, 2005, 20 (3): 177-182. |
10. | Efthimiou P, Kukar M. Lupus pernio: sarcoid-specific cutaneous manifestation associated with chronic sarcoid arthropathy. J Clin Rheumatol, 2011, 17 (6):343. |
11. | Lacomis D. Neurosarcoidosis. Curr Neuropharmacol, 2011, 9 (3):429-436. |
12. | Ebert EC, Kierson M, Hagspiel KD. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol, 2008, 103 (12):3184-3192. |
13. | Morgenthau AS, Iannuzzi MC. Recent advances in sarcoidosis. Chest, 2011, 139 (1): 174-182. |
14. | Mostard RL, Prompers L, Weijers RE, et al. F-18 FDG PET/CT for detecting bone and bone marrow involvement in sarcoidosis patients. Clin Nucl Med, 2012, 37 (1):21-25. |
15. | Hawtin KE, Roddie ME, Mauri FA. pulmonary sarcoidosis: the great pretender. Clin Radiol, 2010, 65 (8): 642-650. |
16. | Hunt BM, Vallières E, Buduhan G, et al. Sarcoidosis as a benign cause of lymphadenopathy in cancer patients. Am J Surg, 2009, 197 (5):629-632. |
17. | Fritscher-Ravens A, Ghanbari A, Topalidis T, et al. Granulomatous mediastinal adenopathy: can endoscopic ultrasound-guided fine-needle aspiration differentiate between tuberculosis and sarcoidosis ? Endoscopy, 2011, 43 (11):955-961. |
18. | Maayan H, Ashkenazi Y, Nagler A, et al. Sarcoidosis and lymphoma: case series and literature review. Sarcoidosis Vasc Diffuse Lung Dis, 2011, 28 (2):146-152. |
19. | Baughman RP, Teirstein AS, Judson MA, et al. Case Control Etiologic Study of Sarcoidosis (ACCESS) research group. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med, 2001, 164 (10 pt 1):1885-1889. |
20. | Izbicki G, Chavko R, Banauch GI, et al. World Trade Center “sarcoid-like” granulomatous pulmonary disease in New York City Fire Department rescue workers. Chest, 2007, 131 (5): 1414-1423. |
21. | Eishi Y, Suga M, Ishige I, et al. Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol, 2002, 40 (1): 198-204. |
22. | Song Z, Marzilli L, Greenlee BM, et al. Mycobacterial catalaseperoxidase is a tissue antigen and target of the adaptive immuneresponse in systemic sarcoidosis. J Exp Med, 2005, 201 (5): 755-767. |
23. | Brewerton DA, Cockburn C, James DC, et al. HLA antigens in sarcoidosis. Clin Exp Immunol, 1977, 27 (2): 227-229. |
24. | Iannuzzi MC, Maliarik MJ, Poisson LM, et al. Sarcoidosis susceptibility and resistance HLA-DQB1 alleles in African Americans. Am J Respir Crit Care Med, 2003, 167 (9): 1225-1231. |
25. | Voorter CE, Amicosante M, Berretta F, et al. HLA classⅡamino acid epitopes as susceptibility markers of sarcoidosis. Tissue Antigens, 2007, 70 (1): 18-27. |
26. | Hofmann S, Franke A, Fischer A, et al. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet, 2008, 40 (9): 1103-1106. |
27. | Grunewald J, Eklund A. Role of CD4+ T cells in sarcoidosis. Proc Am Thorac Soc, 2007, 4 (5): 461-464. |
28. | Agostini C, Adami F, Semenzato G. New pathogenetic insights into the sarcoid granuloma. Curr Opin Rheumatol, 2000, 12 (1): 71-76. |
29. | Wahlstrom J, Katchar K, Wigzell H, et al. Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am J Respir Crit Care Med, 2001, 163 (1): 115-121. |
30. | Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med, 1999, 160 (2): 736-755. |
31. | Baughman RP, Winget DB, Lower EE. Methotrexate is steroid sparing in acute sarcoidosis: results of a double blind, randomized trial. Sarcoidosis Vasc Diffuse Lung Dis, 2000, 17 (1): 60-66. |
32. | Baughman RP, Lower EE, Bradley DA, et al. Etanercept for refractory ocular sarcoidosis: results of a doubleblind randomized trial. Chest, 2005, 128 (2): 1062- 1067. |
33. | Judson MA, Baughman RP, Costabel U, et al. Centocor T48 Sarcoidosis Investigators. Effi cacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J, 2008, 31 (6): 1189-1196. |
34. | Barnett CF, Bonura EJ, Nathan SD, et al. Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience. Chest, 2009, 135 (6): 1455-1461. |
35. | Zaidi AR, Zaidi A, Vaitkus PT. Outcome of heart transplantation in patients with sarcoid cardiomyopathy. J Heart Lung Transplant, 2007, 26 (7): 714-717. |
- 1. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med, 2007, 357 (21):2153-2165.
- 2. Tremblay A, Stather DR, Maceachern P, et al. A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis. Chest, 2009, 136 (2): 340-346.
- 3. 赵辉, 王俊, 李剑锋, 等. 纵隔镜检查在胸部结节病诊断中的价值. 中华医学杂志, 2005, 85 (13): 919-921.
- 4. Dempsey OJ, Paterson EW, Kerr KM, et al. Sarcoidosis. BMJ, 2009, 339 (7721): 620-625.
- 5. Balan A, Hoey ET, Sheerin F, et al. Multi-technique imaging of sarcoidosis. Clin Radiol, 2010, 65 (9):750-760.
- 6. Park HJ, Jung Jl, Chung MH, et al. Typical and atypical manifestations of intrathoracic sarcoidosis. Korean J Radiol, 2009, 10 (6): 623-631.
- 7. Criado E, Sanche Z, Ramiez J, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation. Radiographics, 2010, 30 (6): 1567-1586.
- 8. Fisher KA, Serlin DM, Wilson KC, et al. Sarcoidosis-associated pulmonary hypertension: outcome with long-term epoprostenol treatment. Chest, 2006, 130 (5): 1481-1488.
- 9. Bonfioli AA, Orefice F. Sarcoidosis. Semin Ophthalmol, 2005, 20 (3): 177-182.
- 10. Efthimiou P, Kukar M. Lupus pernio: sarcoid-specific cutaneous manifestation associated with chronic sarcoid arthropathy. J Clin Rheumatol, 2011, 17 (6):343.
- 11. Lacomis D. Neurosarcoidosis. Curr Neuropharmacol, 2011, 9 (3):429-436.
- 12. Ebert EC, Kierson M, Hagspiel KD. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol, 2008, 103 (12):3184-3192.
- 13. Morgenthau AS, Iannuzzi MC. Recent advances in sarcoidosis. Chest, 2011, 139 (1): 174-182.
- 14. Mostard RL, Prompers L, Weijers RE, et al. F-18 FDG PET/CT for detecting bone and bone marrow involvement in sarcoidosis patients. Clin Nucl Med, 2012, 37 (1):21-25.
- 15. Hawtin KE, Roddie ME, Mauri FA. pulmonary sarcoidosis: the great pretender. Clin Radiol, 2010, 65 (8): 642-650.
- 16. Hunt BM, Vallières E, Buduhan G, et al. Sarcoidosis as a benign cause of lymphadenopathy in cancer patients. Am J Surg, 2009, 197 (5):629-632.
- 17. Fritscher-Ravens A, Ghanbari A, Topalidis T, et al. Granulomatous mediastinal adenopathy: can endoscopic ultrasound-guided fine-needle aspiration differentiate between tuberculosis and sarcoidosis ? Endoscopy, 2011, 43 (11):955-961.
- 18. Maayan H, Ashkenazi Y, Nagler A, et al. Sarcoidosis and lymphoma: case series and literature review. Sarcoidosis Vasc Diffuse Lung Dis, 2011, 28 (2):146-152.
- 19. Baughman RP, Teirstein AS, Judson MA, et al. Case Control Etiologic Study of Sarcoidosis (ACCESS) research group. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med, 2001, 164 (10 pt 1):1885-1889.
- 20. Izbicki G, Chavko R, Banauch GI, et al. World Trade Center “sarcoid-like” granulomatous pulmonary disease in New York City Fire Department rescue workers. Chest, 2007, 131 (5): 1414-1423.
- 21. Eishi Y, Suga M, Ishige I, et al. Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol, 2002, 40 (1): 198-204.
- 22. Song Z, Marzilli L, Greenlee BM, et al. Mycobacterial catalaseperoxidase is a tissue antigen and target of the adaptive immuneresponse in systemic sarcoidosis. J Exp Med, 2005, 201 (5): 755-767.
- 23. Brewerton DA, Cockburn C, James DC, et al. HLA antigens in sarcoidosis. Clin Exp Immunol, 1977, 27 (2): 227-229.
- 24. Iannuzzi MC, Maliarik MJ, Poisson LM, et al. Sarcoidosis susceptibility and resistance HLA-DQB1 alleles in African Americans. Am J Respir Crit Care Med, 2003, 167 (9): 1225-1231.
- 25. Voorter CE, Amicosante M, Berretta F, et al. HLA classⅡamino acid epitopes as susceptibility markers of sarcoidosis. Tissue Antigens, 2007, 70 (1): 18-27.
- 26. Hofmann S, Franke A, Fischer A, et al. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet, 2008, 40 (9): 1103-1106.
- 27. Grunewald J, Eklund A. Role of CD4+ T cells in sarcoidosis. Proc Am Thorac Soc, 2007, 4 (5): 461-464.
- 28. Agostini C, Adami F, Semenzato G. New pathogenetic insights into the sarcoid granuloma. Curr Opin Rheumatol, 2000, 12 (1): 71-76.
- 29. Wahlstrom J, Katchar K, Wigzell H, et al. Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am J Respir Crit Care Med, 2001, 163 (1): 115-121.
- 30. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med, 1999, 160 (2): 736-755.
- 31. Baughman RP, Winget DB, Lower EE. Methotrexate is steroid sparing in acute sarcoidosis: results of a double blind, randomized trial. Sarcoidosis Vasc Diffuse Lung Dis, 2000, 17 (1): 60-66.
- 32. Baughman RP, Lower EE, Bradley DA, et al. Etanercept for refractory ocular sarcoidosis: results of a doubleblind randomized trial. Chest, 2005, 128 (2): 1062- 1067.
- 33. Judson MA, Baughman RP, Costabel U, et al. Centocor T48 Sarcoidosis Investigators. Effi cacy of infliximab in extrapulmonary sarcoidosis: results from a randomised trial. Eur Respir J, 2008, 31 (6): 1189-1196.
- 34. Barnett CF, Bonura EJ, Nathan SD, et al. Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience. Chest, 2009, 135 (6): 1455-1461.
- 35. Zaidi AR, Zaidi A, Vaitkus PT. Outcome of heart transplantation in patients with sarcoid cardiomyopathy. J Heart Lung Transplant, 2007, 26 (7): 714-717.