DAI Xiaofu , CHEN Liangwan , CHEN Daozhong
  • （Department of Cardiovascular Surgery,Union Hospital, Fujian Medical University, Fuzhou 350001, P.R.China）;
n-3 polyunsaturated fatty acids; Allograft arteriosclerosis; Intercellular adhesion molecule1; Vascular cell adhesion molecule1; Nuclear factorkappa B
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Abstract: Objective To study the preventive effect of n-3 polyunsaturated fatty acids on allograft arteriosclerosis. Methods Arterial homeotransplant model were created with 480 rats which were divided into four groups. Control group, no n-3 lyunsaturated fatty acids were taken. Group A, n-3 polyunsaturated fatty acids were taken for two weeks before operation with the dose of EPA 600mg/kg. Group B, 300 mg/kg and group C 150 mg/kg were taken respectively. The recipient’s transplanted vessel was excised after 1,7,14,21and 28 days respectively. The tissue pathological variations, ultrastructure variations and expression variations of intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1（VCAM-1）, nuclear factorkappa B（NF-κB） had been observed. Results The pathological changes occurred 7 days after operation in control group and were most prominent on the 28th day, blood vessels were obstructed and the expressions of ICAM-1, VCAM1,NF-κB were markedly intensified than those of group A, B, C (P lt;0.05). The pathological variations of transplanted vessel in group A, B, C occurred later than those in control group. The nonobstruction rates in group A, B, C were better than that in control group. The expressions of ICAM-1， VCAM-1， NF-κB in control group were ber than those in group A， B， C (P lt;0.05). The expressions of ICAM-1， VCAM-1， NF-κB after 1 day or 7 days demonstrated no statistically significant change in group A， B， C （P gt;0.05）. The preventive effect for allograft vessel atheromatosis in group A and group B was ber than that in group C after 14, 21 and 28d (P lt;0.05). There were no significant difference between group A and group B (P gt; 0.05). Conclusion The n-3 polyunsaturated fatty acids can prevent the allograft vessel atheromatosis, the most effective dose of n-3 polyunsaturated fatty acids is 300 mg/kg.

Citation： DAI Xiaofu,CHEN Liangwan,CHEN Daozhong,HUANG Xueshan,WU Xijie.. Preventive Effect of n-3 Polyunsaturated Fatty Acids on Allograft Arteriosclerosis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2007, 14(3): 211-215. doi: Copy