The autograft and non-autograft cannot meet the needs of clinical vascular surgery. Since there are possibilities of thrombus formation in artificial vascular grafts, the methods for deposing the graft using physical and chemical ways or simply seeding with endothelial cells cannot produce satisfactory grafts for vascular operations until now. In order to increase the anticoagulative capacity of artificial vascular graft, it is rational to use genetic engineering methods modifying the endothelial cells to make it express anticoagulative factors stably. Although seeding artificial graft with the genetically engineered endothelial cells can possibly produce a satisfactory graft for vascular surgery, some problems still need to be solved.
Citation： WANG Wen lin,CAI Kaican,WANG Wujun.. Progress in Studies of Seeding Genetically Engineered Endothelial Cell on Artificial Vascular Graft. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2006, 13(1): 39-42. doi: Copy