Objective To report an acute ischemic left ventricular heart failure model of safe, simple, relatively steady, and reproducible in sheep. Methods Fourteen female sheep with a body weight of 36.80±3.43kg were used in this study. Heart failure model was induced by partial occluding the middle left circumflex coronary artery (LCX) combined with pacemaker-induced tachycardia. Hemodynamic measurement was done before and after heart failure, myocardial examination was observed. Results Heart failure model was induced successfully in 10 sheep. Cardiac output dropped from 3.74±0.48L/min to 2.02±0. 51L/min (P〈0. 01), mean arterial pressure decreased from 116. 10± 14.15 mmHg(1kPa = 7.5mmHg) to 68. 10± 14. 72mmHg (P〈0.01), central venous pressure rose from 7. 10±2.18mmHg to 10. 70± 3.50 mmHg (P〈0.05), right ventricular end-diastolic pressure increased from 6.10±3.57mmHg to 9.90±4.41mmHg(P〈0.05), left atrial pressure increased from 8.10±2.13 mmHg to 12.00± 4.57mmHg (P〈0. 01 ), and left ventricular end-diastolic pressure increased from 8. 50± 4. 17mmHg to 13.10± 10. 64mmHg(P〉 0. 05). The myocardial ultrastructure injuries was marked. Conclusions Acute ischemic left ventricular heart failure could be induced by partial occlusion of the middle LCX combined with pacemaker-induced taehyeardia in sheep. This model is simple, easy to manipulate, relatively steady, and reproducible . It may be used for assessing cardiac assist devices.
Citation: LI Zhicheng,CHEN Chang zhi,YE Qing,et al .. Establishment of Acute Ischemic Left Ventricular Heart Failure Model in Sheep. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2006, 13(2): 102-105. doi: Copy