EFFECT EVALUATION OF MEDICAL CALCIUM SULFATE—OsteoSet IN REPAIRING JAW BONE DEFECT_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHENG Xianyu , HE Jiacai.

Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Anhui Medical University, Hefei Anhui, 230032, P.R.China.;

Corresponding author：

Keywords：

Medical calcium sulfate; Bone defect repair; Jaw cystic lesion

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【Abstract】 Objective To investigate the effectiveness of the medical calcium sulfate—OsteoSet bone graft substitute in the treatment of defect after excision of jaw cyst. Methods Between December 2009 and May 2010, 15 cases of jaw cystic lesion were treated，including 9 males and 6 females with an average age of 36.6 years (range, 15-75 years). Orthopantomography (OPT) method was used to measure the cyst size before operation, and the size ranged from 1.5 cm × 1.5 cm to 8.0 cm × 3.0 cm. The range of bone defect was from 1.5 cm × 1.5 cm × 1.5 cm to 8.0 cm × 3.0 cm × 3.0 cm after cyst excision intraoperatively. The patients underwent cyst curettage and OsteoSet bone graft substitutes implantation (2-15 mL). Radiological method was used to evaluate the repair effect of OsteoSet pellets. Results The pathology biopsy was periapical cyst in 7 cases, odontogenic keratocyst in 5 cases, and dentigerous cyst in 3 cases. Fifteen patients were followed up 6-12 months. Thirteen patients achieved wound healing by first intention; 2 cases had longer drainage time (5 and 7 days, respectively), the incision healed after the pressure bandage. Swelling occurred in 1 case after 1 month with no symptom of infection. No postoperative infection and rejection was found. The X-ray examination showed that the materials filled the bone defect well after 1 day of operation. OsteoSet bone graft substitutes were absorbed by one-half after 1 month of operation and totally after 3 months by OPT. The low density area was smaller in the original cysts cavity, and high density in the cysts increased significantly with fuzzy boundaries of cysts. At 6 months after operation， there was no obvious difference in image density between the original cavity and normal bone, and the capsule cavity boundary disappeared, and defect area was full of new bone. Conclusion The medical calcium sulfate—OsteoSet bone graft substitute is an ideal filling material for bone defect.

Citation： ZHENG Xianyu,HE Jiacai.. EFFECT EVALUATION OF MEDICAL CALCIUM SULFATE—OsteoSet IN REPAIRING JAW BONE DEFECT. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(1): 87-90. doi: Copy

1.	fractures. Orthopedics, 2004, 27(1 Supple): s103-107.
2.	evidence for increased angiogenesis in rabbits. J Oral Implantol, 2002, 28(6): 273-278.
3.	Schnee CL, Freese A, Ansell LV. Outcome analysis for adults with spondylolisthesis treated with posterolateral fusion and transpedicular screw fixation. J Neurosurg, 1997, 86(1): 56-63.
4.	Skaggs DL, Samuelson MA, Hale JM, et al. Complications of posterior iliac crest bone grafting in spine surgery in children. Spine (Phila Pa 1976), 2000, 25(18): 2400-2402.
5.	Laurencin C, Khan Y, El-Amin SF. Bone graft substitutes. Expert Rev Med Devices, 2006, 3(1): 49-57.
6.	余红梅, 林朝生. 羟基磷灰石修复颌骨缺损的临床应用. 口腔颌面外科杂志, 2004, 14(2): 154-155.
7.	Blaha JD. Calcium sulfate bone-void filler. Orthopedics, 1998, 21(9): 1017-1019.
8.	田卫东, 李声伟, 乔鞠, 等. 煅石膏与羟基磷灰石复合人工骨的实验研究. 中国口腔种植学杂志, 1998, 3(3): 107-111.
9.	Pecora G, Andreana S, Margarone JE 3rd, et al. Bone regeneration with a calcium sulfate barrier. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1997, 84(4): 424-429.
10.	苏荣玉, 王银龙, 朱铜军, 等. 医用硫酸钙Osteoset 在修复犬下颌骨缺损中的作用. 安徽医科大学学报, 2011, 46(10): 1011-1012.
11.	Watson JT. The use of an injectable bone graft substitute in tibial metaphyseal.
12.	Pietrzak WS, Ronk R. Calcium suflate bone void filler: a review and a look ahead. J Craniofac Surg, 2000, 11(4): 327-344.
13.	Strocchi R, Orsini G, Iezzi G, et al. Bone regeneration with calcium sulfate:.
14.	Dasmah A, Sennerby L, Rasmusson L, et al. Intramembraneous bone tissue responses to calcium sulfate: an experimental study in the rabbit maxilla. Clin Oral Implants Res, 2011. [Epub ahead of print].
15.	Sidqui M, Collin P, Vitte C, et al. Osteoblast adherence and resorption activity of isolated osteoblasts on calcium sulphate hemihydrate. Biomaterials,.
16.	Nilsson M, Wang JS, Wielanek L, et al. Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute. J Bone Joint Surg (Br), 2004, 86(1): 120-125.
17.	Bahn SL. Plaster: A bone substitute. Oral Surg Oral Med Oral Pathol, 1966, 21(5): 672-681.
18.	张劲松, 李雅冬, 季平, 等. 医用硫酸钙(STIMULAN?)在颌骨囊肿手术中的临床应用. 山西医科大学学报, 2007, 38(2): 167-169.
19.	Kelly CM, Wilkins RM, Gitelis S, et al. The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin Orthop Relat Res, 2001, (382): 42-50.
20.	刘鹏, 赵建华, 范伟力, 等. 骨移植替代物医用硫酸钙初步临床应用. 中国修复重建外科杂志, 2006, 20(11): 1066-1069.
21.	, 16(17): 1327-1332.

1. fractures. Orthopedics, 2004, 27(1 Supple): s103-107.
2. evidence for increased angiogenesis in rabbits. J Oral Implantol, 2002, 28(6): 273-278.
3. Schnee CL, Freese A, Ansell LV. Outcome analysis for adults with spondylolisthesis treated with posterolateral fusion and transpedicular screw fixation. J Neurosurg, 1997, 86(1): 56-63.
4. Skaggs DL, Samuelson MA, Hale JM, et al. Complications of posterior iliac crest bone grafting in spine surgery in children. Spine (Phila Pa 1976), 2000, 25(18): 2400-2402.
5. Laurencin C, Khan Y, El-Amin SF. Bone graft substitutes. Expert Rev Med Devices, 2006, 3(1): 49-57.
6. 余红梅, 林朝生. 羟基磷灰石修复颌骨缺损的临床应用. 口腔颌面外科杂志, 2004, 14(2): 154-155.
7. Blaha JD. Calcium sulfate bone-void filler. Orthopedics, 1998, 21(9): 1017-1019.
8. 田卫东, 李声伟, 乔鞠, 等. 煅石膏与羟基磷灰石复合人工骨的实验研究. 中国口腔种植学杂志, 1998, 3(3): 107-111.
9. Pecora G, Andreana S, Margarone JE 3rd, et al. Bone regeneration with a calcium sulfate barrier. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1997, 84(4): 424-429.
10. 苏荣玉, 王银龙, 朱铜军, 等. 医用硫酸钙Osteoset 在修复犬下颌骨缺损中的作用. 安徽医科大学学报, 2011, 46(10): 1011-1012.
11. Watson JT. The use of an injectable bone graft substitute in tibial metaphyseal.
12. Pietrzak WS, Ronk R. Calcium suflate bone void filler: a review and a look ahead. J Craniofac Surg, 2000, 11(4): 327-344.
13. Strocchi R, Orsini G, Iezzi G, et al. Bone regeneration with calcium sulfate:.
14. Dasmah A, Sennerby L, Rasmusson L, et al. Intramembraneous bone tissue responses to calcium sulfate: an experimental study in the rabbit maxilla. Clin Oral Implants Res, 2011. [Epub ahead of print].
15. Sidqui M, Collin P, Vitte C, et al. Osteoblast adherence and resorption activity of isolated osteoblasts on calcium sulphate hemihydrate. Biomaterials,.
16. Nilsson M, Wang JS, Wielanek L, et al. Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute. J Bone Joint Surg (Br), 2004, 86(1): 120-125.
17. Bahn SL. Plaster: A bone substitute. Oral Surg Oral Med Oral Pathol, 1966, 21(5): 672-681.
18. 张劲松, 李雅冬, 季平, 等. 医用硫酸钙(STIMULAN?)在颌骨囊肿手术中的临床应用. 山西医科大学学报, 2007, 38(2): 167-169.
19. Kelly CM, Wilkins RM, Gitelis S, et al. The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin Orthop Relat Res, 2001, (382): 42-50.
20. 刘鹏, 赵建华, 范伟力, 等. 骨移植替代物医用硫酸钙初步临床应用. 中国修复重建外科杂志, 2006, 20(11): 1066-1069.
21. , 16(17): 1327-1332.

Chinese Journal of Reparative and Reconstructive Surgery

EFFECT EVALUATION OF MEDICAL CALCIUM SULFATE—OsteoSet IN REPAIRING JAW BONE DEFECT

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