RESEARCH PROGRESS OF PROTECTIVE EFFECTS OF ALENDRONATE ON ARTICULAR CARTILAGE IN OSTEOARTHRITIS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

HE Dingwen , YIN Ming , LUO Yuanyi , WEI Qiangqiang.

No.1 Department of Orthopaedics, the Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P.R.China. Corresponding author: YIN Ming, E-mail: yinming0791@yahoo.com.cn;

Corresponding author：

Keywords：

Osteoarthritis; Alendronate; Cartilage protective effect

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Objective To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA). Methods The related literature was reviewed and the main achievements in vitro/vivo studies in the fields were summarized. Results ALN can improve the metabolic microenvironment of the articular cartilage in OA, inhibit subchondral bone remodeling, so it has potential protective effect on articular cartilage. Conclusion ALN is expected to become a disease-modifying OA drug in future, but OA treatment still lack a uniform basic and clinical evaluation criteria, so it has guiding significance in development and application of ALN to develope a uniform standard and obtain the clinical data.

Citation： HE Dingwen,YIN Ming,LUO Yuanyi,WEI Qiangqiang.. RESEARCH PROGRESS OF PROTECTIVE EFFECTS OF ALENDRONATE ON ARTICULAR CARTILAGE IN OSTEOARTHRITIS. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(10): 1187-1190. doi: Copy

1.	Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
2.	王哲彦, 王文雅, 张柳. 骨性关节炎的发病机制及其与Wnt/β-catenin信号通路的关系. 中国矫形外科杂志, 2009, 17(23): 1800-1803.
3.	Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
4.	Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
5.	Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
6.	Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
7.	Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
8.	胡宏宇, 张柳, 李彬, 等. 阿仑膦酸钠体外对软骨细胞的影响及对兔前交叉韧带切断后关节软骨和软骨下骨的作用. 中国修复重建外科杂志, 2009, 23(12): 1474-1481.
9.	王哲彦, 王文雅, 张柳, 等. 阿仑膦酸钠对IL-1β体外诱导培养的大鼠膝关节软骨细胞影响的实验研究. 中国修复重建外科杂志, 2011, 25(1): 50-55.
10.	Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
11.	谷锐, 陈廖斌, 汪晖, 等. 阿仑膦酸钠对大鼠骨关节炎影响的实验研究. 武汉大学学报: 医学版, 2009, 30(1): 66-69.
12.	娄方勇, 卫小春. 阿仑膦酸钠对骨质疏松大鼠关节软骨的影响. 中国药物与临床, 2009, 9(4): 261-264.
13.	梁祖建, 李钊, 张还添, 等. 福善美调控软骨下骨骨重塑保护关节软骨的机制研究. 中国骨质疏松杂志, 2009, 15(3): 206-210.
14.	李强, 张柳, 李震, 等. 阿仑膦酸钠对前交叉韧带切断大鼠关节软骨退变的影响. 中国矫形外科杂志, 2010, 18(14): 1200-1204.
15.	程潭, 张柳, 李震, 等. 阿仑膦酸钠对兔膝骨关节炎关节软骨及软骨下骨保护的作用. 中国老年学杂志, 2010, 30(24): 3695-3698.
16.	Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
17.	Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
18.	Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
19.	Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
20.	柯贤柱, 石芳, 李飞. 阿仑膦酸钠联合骨肽注射液治疗膝骨性关节炎疗效分析. 中国误诊学杂志, 2011, 11(31): 7646-7647.
21.	李亚芹. 针刀松解术联合阿仑膦酸钠治疗膝关节退行性骨病. 临床和实验医学杂志, 2011, 10(11): 853, 856.
22.	Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.

1. Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
2. 王哲彦, 王文雅, 张柳. 骨性关节炎的发病机制及其与Wnt/β-catenin信号通路的关系. 中国矫形外科杂志, 2009, 17(23): 1800-1803.
3. Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
4. Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
5. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
6. Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
7. Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
8. 胡宏宇, 张柳, 李彬, 等. 阿仑膦酸钠体外对软骨细胞的影响及对兔前交叉韧带切断后关节软骨和软骨下骨的作用. 中国修复重建外科杂志, 2009, 23(12): 1474-1481.
9. 王哲彦, 王文雅, 张柳, 等. 阿仑膦酸钠对IL-1β体外诱导培养的大鼠膝关节软骨细胞影响的实验研究. 中国修复重建外科杂志, 2011, 25(1): 50-55.
10. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
11. 谷锐, 陈廖斌, 汪晖, 等. 阿仑膦酸钠对大鼠骨关节炎影响的实验研究. 武汉大学学报: 医学版, 2009, 30(1): 66-69.
12. 娄方勇, 卫小春. 阿仑膦酸钠对骨质疏松大鼠关节软骨的影响. 中国药物与临床, 2009, 9(4): 261-264.
13. 梁祖建, 李钊, 张还添, 等. 福善美调控软骨下骨骨重塑保护关节软骨的机制研究. 中国骨质疏松杂志, 2009, 15(3): 206-210.
14. 李强, 张柳, 李震, 等. 阿仑膦酸钠对前交叉韧带切断大鼠关节软骨退变的影响. 中国矫形外科杂志, 2010, 18(14): 1200-1204.
15. 程潭, 张柳, 李震, 等. 阿仑膦酸钠对兔膝骨关节炎关节软骨及软骨下骨保护的作用. 中国老年学杂志, 2010, 30(24): 3695-3698.
16. Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
17. Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
18. Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
19. Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
20. 柯贤柱, 石芳, 李飞. 阿仑膦酸钠联合骨肽注射液治疗膝骨性关节炎疗效分析. 中国误诊学杂志, 2011, 11(31): 7646-7647.
21. 李亚芹. 针刀松解术联合阿仑膦酸钠治疗膝关节退行性骨病. 临床和实验医学杂志, 2011, 10(11): 853, 856.
22. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF PROTECTIVE EFFECTS OF ALENDRONATE ON ARTICULAR CARTILAGE IN OSTEOARTHRITIS

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