CELL-BASED APPROACHES TO PROMOTE BONE REGENERATION IN DISTRACTION OSTEOGENESIS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

MA Dongyang ¹ , MAO Tianqiu ²

1Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou Gansu, 730050, P.R.China;;
2Department of Maxillofacial Surgery, School of Stomatology Fourth Military Medical University. Corresponding author: MA Dongyang, E-mail: doctormdy@hotmail.com;

Corresponding author：

Keywords：

Cell therapy; Distraction osteogenesis; Bone regeneration

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Objective To summarize the recent progress of cell-based approaches for promoting bone regeneration in distraction osteogenesis (DO). Methods Recent literature concerning enhancement of bone regeneration following DO using cell-based approaches was reviewed and analyzed. Results An overview of 4 different cell-based approaches was mainly provided: single cell injection, cell scaffold-based strategies/injectable tissue engineered bone, microtissue technology or cell aggregate technology, and stem cell gene therapy. Each has its advantages and disadvantages. Other methods are still in the experimental research except that compound injection of bone marrow mesechymal stem cells and platelet-rich plasma has been applied to clinical practice. Conclusion The cell-based approach is a promising strategy in the field of bone regenerative medicine. These approaches have bright future in promoting bone regeneration and reducing the treatment period in DO in the clinical application. However, well-designed preclinical studies are required to establish safe and effective guidelines for cell-based approaches to promoting bone regeneration during DO.

Citation： MA Dongyang,MAO Tianqiu. CELL-BASED APPROACHES TO PROMOTE BONE REGENERATION IN DISTRACTION OSTEOGENESIS. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(12): 1512-1515. doi: Copy

1.	Sailhan F. Bone lengthening (distraction osteogenesis): a literature review. Osteoporos Int, 2011, 22(6): 2011-2015.
2.	Sabharwal S. Enhancement of bone formation during distraction osteogenesis: pediatric applications. J Am Acad Orthop Surg, 2011, 19(2): 101-111.
3.	Devine MJ, Mierisch CM, Jang E, et al. Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res, 2002, 20(6): 1232-1239.
4.	Granero-Moltó F, Weis JA, Miga MI, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells, 2009, 27(8): 1887-1898.
5.	Hamanishi C, Yoshii T, Totani Y, et al. Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry. Clin Orthop Relat Res, 1994, (303): 250-255.
6.	Hernigou P, Poignard A, Beaujean F, et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg (Am), 2005, 87(7): 1430-1437.
7.	Peters A, Toben D, Lienau J, et al. Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing. Tissue Eng Part A, 2009, 15(10): 2947-2954.
8.	Takushima A, Kitano Y, Harii K. Osteogenic potential of cultured periosteal cells in a distracted bone gap in rabbits. J Surg Res, 1998, 78(1): 68-77.
9.	Qi M, Hu J, Zou S, et al. Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats. J Craniomaxillofac Surg, 2006, 34(5): 283-289.
10.	Shao Z, Liu B, Peng Q, et al. Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible. Plast Reconstr Surg, 2007, 119(2): 500-507.
11.	Takamine Y, Tsuchiya H, Kitakoji T, et al. Distraction osteogenesis enhanced by osteoblastlike cells and collagen gel. Clin Orthop Relat Res, 2002, (399): 240-246.
12.	Dai W, Hale SL, Kay GL, et al. Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technology. Regen Med, 2009, 4(3): 387-395.
13.	Kinoshita K, Hibi H, Yamada Y, et al. Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material. J Craniofac Surg, 2008, 19(1): 80-87.
14.	Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone, 2007, 40(2): 522-528.
15.	Intini G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials, 2009, 30(28): 4956-4966.
16.	Sands JJ, Nudo SA, Ashford RG, et al. Antibodies to topical bovine thrombin correlate with access thrombosis. Am J Kidney Dis, 2000, 35(5): 796-801.
17.	Bueno EM, Glowacki J. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol, 2009, 5(12): 685-697.
18.	Kelm JM, Fussenegger M. Scaffold-free cell delivery for use in regenerative medicine. Adv Drug Deliv Rev, 2010, 62(7-8): 753-764.
19.	Kneser U, Stangenberg L, Ohnolz J, et al. Evaluation of processed bovine cancellous bone matrix seeded with syngenic osteoblasts in a critical size calvarial defect rat model. J Cell Mol Med, 2006, 10(3): 695-707.
20.	Langenbach F, Naujoks C, Smeets R, et al. Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering. Clin Oral Investig, 2012. [Epub ahead of print].
21.	Ma D, Zhong C, Yao H, et al. Engineering injectable bone using bone marrow stromal cell aggregates. Stem Cell Devel, 2011, 20(6): 989-999.
22.	Tseng SS, Lee MA, Reddi AH. Nonunions and the potential of stem cells in fracture-healing. J Bone Joint Surg (Am), 2008, 90 Suppl 1: 92-98.
23.	Hu J, Qi MC, Zou SJ, et al. Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats. J Orthop Res, 2007, 25(2): 241-251.
24.	Jiang X, Zou S, Ye B, et al. bFGF-Modified BMMSCs enhance bone regeneration following distraction osteogenesis in rabbits. Bone, 2010, 46(4): 1156-1161.

1. Sailhan F. Bone lengthening (distraction osteogenesis): a literature review. Osteoporos Int, 2011, 22(6): 2011-2015.
2. Sabharwal S. Enhancement of bone formation during distraction osteogenesis: pediatric applications. J Am Acad Orthop Surg, 2011, 19(2): 101-111.
3. Devine MJ, Mierisch CM, Jang E, et al. Transplanted bone marrow cells localize to fracture callus in a mouse model. J Orthop Res, 2002, 20(6): 1232-1239.
4. Granero-Moltó F, Weis JA, Miga MI, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells, 2009, 27(8): 1887-1898.
5. Hamanishi C, Yoshii T, Totani Y, et al. Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry. Clin Orthop Relat Res, 1994, (303): 250-255.
6. Hernigou P, Poignard A, Beaujean F, et al. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg (Am), 2005, 87(7): 1430-1437.
7. Peters A, Toben D, Lienau J, et al. Locally applied osteogenic predifferentiated progenitor cells are more effective than undifferentiated mesenchymal stem cells in the treatment of delayed bone healing. Tissue Eng Part A, 2009, 15(10): 2947-2954.
8. Takushima A, Kitano Y, Harii K. Osteogenic potential of cultured periosteal cells in a distracted bone gap in rabbits. J Surg Res, 1998, 78(1): 68-77.
9. Qi M, Hu J, Zou S, et al. Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats. J Craniomaxillofac Surg, 2006, 34(5): 283-289.
10. Shao Z, Liu B, Peng Q, et al. Transplantation of osteoblast-like cells to the distracted callus in the rabbit mandible. Plast Reconstr Surg, 2007, 119(2): 500-507.
11. Takamine Y, Tsuchiya H, Kitakoji T, et al. Distraction osteogenesis enhanced by osteoblastlike cells and collagen gel. Clin Orthop Relat Res, 2002, (399): 240-246.
12. Dai W, Hale SL, Kay GL, et al. Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technology. Regen Med, 2009, 4(3): 387-395.
13. Kinoshita K, Hibi H, Yamada Y, et al. Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material. J Craniofac Surg, 2008, 19(1): 80-87.
14. Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones. Bone, 2007, 40(2): 522-528.
15. Intini G. The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials, 2009, 30(28): 4956-4966.
16. Sands JJ, Nudo SA, Ashford RG, et al. Antibodies to topical bovine thrombin correlate with access thrombosis. Am J Kidney Dis, 2000, 35(5): 796-801.
17. Bueno EM, Glowacki J. Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol, 2009, 5(12): 685-697.
18. Kelm JM, Fussenegger M. Scaffold-free cell delivery for use in regenerative medicine. Adv Drug Deliv Rev, 2010, 62(7-8): 753-764.
19. Kneser U, Stangenberg L, Ohnolz J, et al. Evaluation of processed bovine cancellous bone matrix seeded with syngenic osteoblasts in a critical size calvarial defect rat model. J Cell Mol Med, 2006, 10(3): 695-707.
20. Langenbach F, Naujoks C, Smeets R, et al. Scaffold-free microtissues: differences from monolayer cultures and their potential in bone tissue engineering. Clin Oral Investig, 2012. [Epub ahead of print].
21. Ma D, Zhong C, Yao H, et al. Engineering injectable bone using bone marrow stromal cell aggregates. Stem Cell Devel, 2011, 20(6): 989-999.
22. Tseng SS, Lee MA, Reddi AH. Nonunions and the potential of stem cells in fracture-healing. J Bone Joint Surg (Am), 2008, 90 Suppl 1: 92-98.
23. Hu J, Qi MC, Zou SJ, et al. Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats. J Orthop Res, 2007, 25(2): 241-251.
24. Jiang X, Zou S, Ye B, et al. bFGF-Modified BMMSCs enhance bone regeneration following distraction osteogenesis in rabbits. Bone, 2010, 46(4): 1156-1161.

Chinese Journal of Reparative and Reconstructive Surgery

CELL-BASED APPROACHES TO PROMOTE BONE REGENERATION IN DISTRACTION OSTEOGENESIS

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