TRANSPLANTATION OF NEURAL STEM CELLS AND BONE MARROW MESENCHYMAL STEM CELLS INTREATMENT OF SPINAL CORD INJURY_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

XU Chaojin.

Department of Histology and Embryology, Wenzhou Medical College, Wenzhou Zhejiang, 325035, P.R.China.;

Corresponding author：

Keywords：

Neural stem cells; Bone marrow mesenchymal stem cells; Immune characteristic; Spinal cord injury; Cell transplantation

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】 Objective To review the progress in the treatment of spinal cord injury (SCI) by graft of neural
stem cells (NSCs) or bone marrow mesenchymal stem cells (BMSCs) as well as immune characteristics of two stem
cells. Methods Different kinds of documents were widely collected, and then immunologic characteristics of NSCs and
BMSCs were summarized. The therapy of SCI by stem cell transplantation was reviewed. Additionally, some problems in
treatment were analyzed. Results Experimental study showed that graft of NSCs and BMSCs can promote the functional
recovery of the injured spinal cord in animals. Due to immunologic properties of two stem cells, rejection reaction of
transplantation could produce a harmful effect on SCI treatment. Conclusion Transplantation of NSCs or BMSCs might be
an effective measure for SCI treatment, but immunologic rejection reaction must be considered.

Citation： XU Chaojin.. TRANSPLANTATION OF NEURAL STEM CELLS AND BONE MARROW MESENCHYMAL STEM CELLS INTREATMENT OF SPINAL CORD INJURY. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(2): 186-189. doi: Copy

1.	Webber DJ, Bradbury EJ, McMahon SB, et al. Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med, 2007, 2 (6): 929-945.
2.	Xu CJ, Xu L, Huang LD, et al. Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats. Neuropathol Appl Neurobiol, 2011, 37(2): 135-155.
3.	Xu L, Xu C, Lü HZ, et al. Long-term fate of allogeneic neural stem cells following transplantation into injured spinal cord. Stem Cell Rev, 2010, 6 (1): 121-136.
4.	Cummings BJ, Uchida N, Tamaki SJ, et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A, 2005, 102 (39): 14069-14074.
5.	Salazar DL, Uchida N, Hamers FP, et al. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One, 2010, 5(8): 15.
6.	Shihabuddin LS, Horner PJ, Ray J, et al. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci, 2000, 20 (23): 8727-8735.
7.	Karimi-Abdolrezaee S, Eftekharpour E, Wang J, et al. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci, 2006, 26 (13): 3377-3389.
8.	Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord stem/progenitor cells for spinal cord injury. J Neurotrauma, 2007, 24 (5): 835-845.
9.	Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A, 2004, 101 (52): 18117-18122.
10.	Kimura A, Ohmori T, Ohkawa R, et al. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells, 2007, 25(1): 115-124.
11.	Al Nimer F, Wennersten A, Holmin S, et al. MHC expression after human neural stem cell transplantation to brain contused rats. Neuroreport, 2004, 15 (12): 1871-1875.
12.	Yin L, Fu SL, Shi GY, et al. Expression and regulation of major histocompatibility complex on neural stem cells and their lineages. Stem Cells Dev, 2008, 17 (1): 53-65.
13.	Pluchino S, Gritti A, Blezer E, et al. Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol, 2009, 66(3): 343-354.
14.	Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci, 2008, 265(1-2): 102-104.
15.	Lee JM, Yan P, Xiao Q, et al. Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J Neurosci, 2008, 28(12): 3141-3149.
16.	Miller RH, Bai L, Lennon DP, et al. The potential of mesenchymal stem cells for neural repair. Discov Med, 2010, 9(46): 236-242.
17.	Sheth RN, Manzano G, Li X, et al. Transplantation of human bone marrow-derived stromal cells into the contused spinal cord of nude rats. J Neurosurg Spine, 2008, 8(2): 153-162.
18.	Kim KN, Oh SH, Lee KH, et al. Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord. Acta Neurochir Suppl, 2006, 99(1): 133-136.
19.	Nandoe Tewarie RD, Hurtado A, Ritfeld GJ, et al. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J Neurotrauma, 2009, 26(12): 2313-2322.
20.	Cizkova D, Novotna I, Slovinska L, et al. Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury. J Neurotrauma, 2011, 28(9): 1951-1961.
21.	Vaquero J, Zurita M. Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol, 2009, 24 (1): 107-116.
22.	Koda M, Okada S, Nakayama T, et al. Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. NeuroReport, 2005, 16 (16): 1763-1767.
23.	Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood, 2007, 110 (10): 3499-3506.
24.	Dupuis L, Pehar M, Cassina P, et al. Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A, 2008, 105 (2): 740-745.
25.	Lee WS, Suzuki Y, Graves SS, et al. Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biol Blood Marrow Transplant, 2011, 17 (4): 465-475.
26.	Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood, 2005, 106(5): 1755-1761.
27.	Chung YC, Ma MC, Huang BY, et al. Protection of bone marrow-derived CD45+/CD34-/lin- stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats. Chin J Physiol, 2011, 54(3): 169-182.
28.	Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol, 2007, 61(3): 219-227.

1. Webber DJ, Bradbury EJ, McMahon SB, et al. Transplanted neural progenitor cells survive and differentiate but achieve limited functional recovery in the lesioned adult rat spinal cord. Regen Med, 2007, 2 (6): 929-945.
2. Xu CJ, Xu L, Huang LD, et al. Combined NgR vaccination and neural stem cell transplantation promote functional recovery after spinal cord injury in adult rats. Neuropathol Appl Neurobiol, 2011, 37(2): 135-155.
3. Xu L, Xu C, Lü HZ, et al. Long-term fate of allogeneic neural stem cells following transplantation into injured spinal cord. Stem Cell Rev, 2010, 6 (1): 121-136.
4. Cummings BJ, Uchida N, Tamaki SJ, et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A, 2005, 102 (39): 14069-14074.
5. Salazar DL, Uchida N, Hamers FP, et al. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One, 2010, 5(8): 15.
6. Shihabuddin LS, Horner PJ, Ray J, et al. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci, 2000, 20 (23): 8727-8735.
7. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, et al. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci, 2006, 26 (13): 3377-3389.
8. Parr AM, Kulbatski I, Tator CH. Transplantation of adult rat spinal cord stem/progenitor cells for spinal cord injury. J Neurotrauma, 2007, 24 (5): 835-845.
9. Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A, 2004, 101 (52): 18117-18122.
10. Kimura A, Ohmori T, Ohkawa R, et al. Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. Stem Cells, 2007, 25(1): 115-124.
11. Al Nimer F, Wennersten A, Holmin S, et al. MHC expression after human neural stem cell transplantation to brain contused rats. Neuroreport, 2004, 15 (12): 1871-1875.
12. Yin L, Fu SL, Shi GY, et al. Expression and regulation of major histocompatibility complex on neural stem cells and their lineages. Stem Cells Dev, 2008, 17 (1): 53-65.
13. Pluchino S, Gritti A, Blezer E, et al. Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol, 2009, 66(3): 343-354.
14. Ben-Hur T. Immunomodulation by neural stem cells. J Neurol Sci, 2008, 265(1-2): 102-104.
15. Lee JM, Yan P, Xiao Q, et al. Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J Neurosci, 2008, 28(12): 3141-3149.
16. Miller RH, Bai L, Lennon DP, et al. The potential of mesenchymal stem cells for neural repair. Discov Med, 2010, 9(46): 236-242.
17. Sheth RN, Manzano G, Li X, et al. Transplantation of human bone marrow-derived stromal cells into the contused spinal cord of nude rats. J Neurosurg Spine, 2008, 8(2): 153-162.
18. Kim KN, Oh SH, Lee KH, et al. Effect of human mesenchymal stem cell transplantation combined with growth factor infusion in the repair of injured spinal cord. Acta Neurochir Suppl, 2006, 99(1): 133-136.
19. Nandoe Tewarie RD, Hurtado A, Ritfeld GJ, et al. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J Neurotrauma, 2009, 26(12): 2313-2322.
20. Cizkova D, Novotna I, Slovinska L, et al. Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury. J Neurotrauma, 2011, 28(9): 1951-1961.
21. Vaquero J, Zurita M. Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histol Histopathol, 2009, 24 (1): 107-116.
22. Koda M, Okada S, Nakayama T, et al. Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. NeuroReport, 2005, 16 (16): 1763-1767.
23. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood, 2007, 110 (10): 3499-3506.
24. Dupuis L, Pehar M, Cassina P, et al. Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proc Natl Acad Sci U S A, 2008, 105 (2): 740-745.
25. Lee WS, Suzuki Y, Graves SS, et al. Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Biol Blood Marrow Transplant, 2011, 17 (4): 465-475.
26. Zappia E, Casazza S, Pedemonte E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood, 2005, 106(5): 1755-1761.
27. Chung YC, Ma MC, Huang BY, et al. Protection of bone marrow-derived CD45+/CD34-/lin- stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats. Chin J Physiol, 2011, 54(3): 169-182.
28. Gerdoni E, Gallo B, Casazza S, et al. Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol, 2007, 61(3): 219-227.

Chinese Journal of Reparative and Reconstructive Surgery

TRANSPLANTATION OF NEURAL STEM CELLS AND BONE MARROW MESENCHYMAL STEM CELLS INTREATMENT OF SPINAL CORD INJURY

Abstract Full text Figures/Tables Video References Cited by

Format

Content