BIOMECHANICAL ANALYSIS OF BILATERAL FACET JOINT STABILIZATION FOR POSTERIOR CERVICAL SPINE RECONSTRUCTION WITH BIO-DERIVED TENDON IN GOATS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WANG Beiyu ¹ , LIU Hao ¹ , HOU Weiguang ² , XIE Huiqi ³ , SONG Yueming ¹ , HONG Ying ⁴ , SHI Rui ¹ , MA Litai. ¹

1Department of Orthopedics, 3Divsion of Stem Cell and TissueEngineering, State Key Laboratory of Biotherapy, 4Operation Room, West China Hospital of Sichuan University, Chengdu Sichuan,610041, P.R.China;;
2No. 363 Hospital of Chengdu.;

Corresponding author：

Keywords：

Cervical posterior ligament complex; Biomechanics; Dynamic stability; Bio-derived tendon

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Objective There is few report on dynamic stabil ization for posterior cervical reconstruction. To investigate the biomechanical properties of a novel cervical spine posterior fixation using the bio-derived freeze-dried tendon in posterior cervical spine reconstruction. Methods The palmaris longus flexor tendon and metacarpal extensor tendon were collected from the death donors’ stump to prepare bio-derived tendon. Twenty fresh cervical vertebrae (C1-7) were harvested from goats and were randomly divided into 4 groups (n=5): intact group (group A); injury control group (group B); screwrods fixation group, fixed with screw-rods on C3，4 (group C); tendon reconstruction group, cross-fixed with bio-derived freezedried tendon on C3，4 bilatera facet joints (group D). The range of motion (ROM) values in flexion, extension, lateral bending, and axial rotation were measured. Results In flexion, the ROM values of group C were significantly lower than those of the other 3 groups (P lt; 0.05), and the ROM values of group B were significantly higher than those of groups A and D (P lt; 0.05). In extension, lateral bending, and axial rotation, the ROM values of group C were significantly lower than those of groups A, B, and D (P lt; 0.05), and no significant difference was found within the other 3 groups (P gt; 0.05). Conclusion The novel cervical spine posterior fixation using the bio-derived frozen-dried tendon can provide enough stabil ity in flexion motion, but it can not limit the lateral bending and axial rotation motion, which can provide dynamic stabil ization in animal model.

Citation： WANG Beiyu,LIU Hao,HOU Weiguang,XIE Huiqi,SONG Yueming,HONG Ying,SHI Rui,MA Litai.. BIOMECHANICAL ANALYSIS OF BILATERAL FACET JOINT STABILIZATION FOR POSTERIOR CERVICAL SPINE RECONSTRUCTION WITH BIO-DERIVED TENDON IN GOATS. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(4): 396-400. doi: Copy

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2.	Harris JH, Yeakley JW. Hyperextension-dislocation of the cervical spine. Ligament injuries demonstrated by magnetic resonance imaging. J Bone Joint Surg (Br), 1982, 74(4): 567-570.
3.	王利, 宋卫, 姜长明, 等. 颈椎棘上棘间韧带生物力学研究. 医用生物力学, 1999, 14(1): 50-53.
4.	Sharma M, Langrana NA, Rodriguez J. Role of ligaments and facets in lumbar spinal stability. Spine (Phila Pa 1976), 1995, 20(8): 887-900.
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6.	Hadley MN, Fitzpatrick BC, Sonntag VK, et al. Facet fracture dislocation injuries of the cervical spine. Neurosurgery, 1992, 30(5): 661-666.
7.	成俊, 宋跃明, 刘浩, 等. 内固定结合外固定治疗严重下颈椎屈曲扭伤. 临床骨科杂志, 2006, 9(2): 137-138.
8.	刘立岷, 宋跃明, 刘浩, 等. 后-前路联合手术治疗下颈椎骨折脱位伴关节突交锁. 中华创伤杂志, 2007, 23(1): 25-28.
9.	Schnake KJ, Schaeren S, Jeanneret B. Dynamic stabilization in addition to decompression for lumbar spinal stenosis with degenerative spondylolisthesis. Spine (Phila Pa 1976), 2006, 31(4): 442-449.
10.	王伟, 任龙喜, 张彤童, 等. 保留颈后方韧带复合体对单开门颈椎板成形术生物力学特性的影响. 中国脊柱脊髓杂志, 2007, 17(2): 122-125.
11.	Wen N, Lavaste F, Santin JJ, et al. Three-dimensional biomechanical properties of the human spine in vitro. I. Analysis of normal motion. Eur Spine J, 1993, 2(1): 2-11.
12.	刘洋, 袁文. 脊柱非融合技术生物力学机制. 脊柱外科杂志, 2007, 5(4): 248-251.
13.	Wilke HJ, Kettler A, Claes LE. Are sheep spines a valid biomechanical model for human spines? Spine (Phila Pa 1976), 1997, 22(20): 2365-2374.
14.	Kandziora F, Pflugmacher R, Scholz M, et al. Comparison between sheep and human cervical spines: an anatomic, radiographic, bone mineral density, and biomechanical study. Spine (Phila Pa 1976), 2001, 26(9): 1028-1037.
15.	杨志明. 修复重建外科学. 北京: 人民卫生出版社, 2001: 92-108.
16.	Smit TH, Krijnen MR, van Dijk M, et al. Application of polylactides in spinal cages: studies in a goat model. J Mater Sci Mater Med, 2006, 17(12): 1237-1244.
17.	周悦婷, 项舟, 阳富春, 等. 生物衍生材料构建组织工程肌腱体内植入的实验研究. 中国修复重建外科杂志, 2003, 17(2): 152-156.

1. Allen BL Jr, Ferguson RL, Lehmann TR, et al. A mechanistic classification of closed, indirect fractures and dislocations of the lower cervical spine. Spine (Phila Pa 1976), 1982, 7(1): 1-27.
2. Harris JH, Yeakley JW. Hyperextension-dislocation of the cervical spine. Ligament injuries demonstrated by magnetic resonance imaging. J Bone Joint Surg (Br), 1982, 74(4): 567-570.
3. 王利, 宋卫, 姜长明, 等. 颈椎棘上棘间韧带生物力学研究. 医用生物力学, 1999, 14(1): 50-53.
4. Sharma M, Langrana NA, Rodriguez J. Role of ligaments and facets in lumbar spinal stability. Spine (Phila Pa 1976), 1995, 20(8): 887-900.
5. Augustus A, White III, Manahar M. The Problem of Clinical Instability in the Human Spine: A Systematic Approach//Panjabi MM, eds. Clinical biomechanics of the spine. Philadelphia: JB Lippincott, 1990: 278-378.
6. Hadley MN, Fitzpatrick BC, Sonntag VK, et al. Facet fracture dislocation injuries of the cervical spine. Neurosurgery, 1992, 30(5): 661-666.
7. 成俊, 宋跃明, 刘浩, 等. 内固定结合外固定治疗严重下颈椎屈曲扭伤. 临床骨科杂志, 2006, 9(2): 137-138.
8. 刘立岷, 宋跃明, 刘浩, 等. 后-前路联合手术治疗下颈椎骨折脱位伴关节突交锁. 中华创伤杂志, 2007, 23(1): 25-28.
9. Schnake KJ, Schaeren S, Jeanneret B. Dynamic stabilization in addition to decompression for lumbar spinal stenosis with degenerative spondylolisthesis. Spine (Phila Pa 1976), 2006, 31(4): 442-449.
10. 王伟, 任龙喜, 张彤童, 等. 保留颈后方韧带复合体对单开门颈椎板成形术生物力学特性的影响. 中国脊柱脊髓杂志, 2007, 17(2): 122-125.
11. Wen N, Lavaste F, Santin JJ, et al. Three-dimensional biomechanical properties of the human spine in vitro. I. Analysis of normal motion. Eur Spine J, 1993, 2(1): 2-11.
12. 刘洋, 袁文. 脊柱非融合技术生物力学机制. 脊柱外科杂志, 2007, 5(4): 248-251.
13. Wilke HJ, Kettler A, Claes LE. Are sheep spines a valid biomechanical model for human spines? Spine (Phila Pa 1976), 1997, 22(20): 2365-2374.
14. Kandziora F, Pflugmacher R, Scholz M, et al. Comparison between sheep and human cervical spines: an anatomic, radiographic, bone mineral density, and biomechanical study. Spine (Phila Pa 1976), 2001, 26(9): 1028-1037.
15. 杨志明. 修复重建外科学. 北京: 人民卫生出版社, 2001: 92-108.
16. Smit TH, Krijnen MR, van Dijk M, et al. Application of polylactides in spinal cages: studies in a goat model. J Mater Sci Mater Med, 2006, 17(12): 1237-1244.
17. 周悦婷, 项舟, 阳富春, 等. 生物衍生材料构建组织工程肌腱体内植入的实验研究. 中国修复重建外科杂志, 2003, 17(2): 152-156.

Chinese Journal of Reparative and Reconstructive Surgery

BIOMECHANICAL ANALYSIS OF BILATERAL FACET JOINT STABILIZATION FOR POSTERIOR CERVICAL SPINE RECONSTRUCTION WITH BIO-DERIVED TENDON IN GOATS

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