• Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;
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Objective To summary the functional roles and molecular mechanisms of microRNA (miRNA) in osteoblast differentiation so as to supply information for basic and cl inical researches. Methods Recent l iterature concerning miRNA in osteoblast differentiation was reviewed. The information was classified and summarized. Results miRNAs critically regulate bone morphogenetic protein, transforming growth factor β, and Wnt/β-catenin signal ing pathways during osteoblast differentiation. In pathological conditions, especially in some disorders of abnormal osteoblast differentiation, downregulated miRNA expression has been observed. Conclusion miRNA may represent a novel biomarker for diagnosis, and a candidate target therapies for the disorders with abnormal osteoblast differentiation.

Citation: ZHOU Mingliang,LI Mi,YU Xijie. .. REGULATION OF microRNA IN OSTEOBLAST DIFFERENTIATION AND ITS CLINICAL SIGNIFICANCE. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(6): 755-759. doi: Copy