SONG Wei , WANG Fuyou , YANG Liu.
  • Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, P.R.China.;
Calcified zone; Uncalcified cartilage zone; Subchondral bone; Osteoarthritis; Interface tissue engineering
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To review the structure and function of the calcified cartilage zone and its role in the pathogenesis of osteoarthritis (OA). Methods Recent l iterature about calcified zone was reviewed and analyzed in terms of architecture, composition, biomechanics, and biological function. Results Calcified zone has particular structure and material properties, and functions as a semi permeable membrane; chondrocytes in the calcified zone retain some characteristics of growth plate cells, which play a crucial role in cartilage function maintenance and pathogenesis of OA. Therefore, reconstruction
of the calcified zone at osteochondral conjunction has become one of the hot research in the fields of interface tissue engineering. Conclusion It is necessary to pay more attention to calcified cartilage zone, which is important for both the treatment of OA and the preparation of tissue engineered osteochondral composite.

Citation： SONG Wei,WANG Fuyou,YANG Liu.. RESEARCH PROGRESS OF CALCIFIED CARTILAGE ZONE. Chinese Journal of Reparative and Reconstructive Surgery, 2011, 25(11): 1339-1342. doi: Copy