LIU Jinchun , LIU Xia , CAO Yilin.
  • Department of Research Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences &;
  • Peking Union Medical College, Beijing, 100144, P.R.China.;
Cartilage tissue engineering; Bone marrow mesenchymal stem cells; Chondrogenic differentiation; Growth factor Induction
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Objective To review the research progress of the current methods of inducing bone marrow mesenchymal stem cells (BMSCs) to chondrogenic differentiation in vitro so as to provide references for researches in cartilage tissue engineering. Methods Various methods of inducing BMSCs differentiation into the chondrogenic l ineage in vitro in
recent years were extensively reviewed and analyzed. Results Adding exogenous growth factors is still the mainly method
of inducing BMSCs differentiation into the chondrogenic l ineage; among the members, transforming growth factor β (TGF-β) family is recognized as the most important chondrogenic induction factor. Other important inducing factors include various chemical factors, physical factors, transgenic methods, and the microenvironmental induction. But the problems of low inducing efficiency and unstable inducing effects still exist. Conclusion The progress of chondrogenic induction of BMSCs promotes its util ization in cartilage tissue engineering. Further researches are needed for establ ishing more efficient, simpler, and safer inducing methods.

Citation： LIU Jinchun,LIU Xia,CAO Yilin.. PROGRESS OF METHODS OF INDUCING BONE MARROW MESENCHYMAL STEM CELLS INTO CHONDROCYTES IN VITRO. Chinese Journal of Reparative and Reconstructive Surgery, 2011, 25(5): 618-623. doi: Copy