ZUO Qiang , DONG Lele , FAN Jianjun.
  • Department of Orthopedics, the First Affiliated Hospital of Baotou Medical College, Baotou Inner Mongolia, 014010, P.R.China;
Tendon injury; Tendon adhesion; Hyaluronic acid derivative; Rabbit
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Objective To evaluate the feasibility of Seprafilm anti-adhesion membrane, a hyaluronic acid (HA) derivative, on prevention of adhesion in acute injured tendon. Methods Eighteen 4-month-old Chinese white rabbits (half males and half females, weighing 2.0-2.5 kg) were made the laceration models of the bilateral second and third toes of hindpaw. According to different treatments, the rabbits were randomly divided into 4 groups (n=18). The second toe of right hindpaw was wrapped with Seprafilm anti-adhesion membrane (group A); the third toe of right hindpaw was wrapped with polylactic acid membrane (group B); the second toe of left hindpaw was coated with sodium hyaluronate gel (group C); and the third toe of left hindpaw did not treated, as control group (group D). The general condition was observed; the range of motion (ROM) of distal interphalangeal joint was measured; the gross observation and histological observation were performed at 1, 2, and 4 weeks, then the degree of adhesion was graded. Results All rabbits survived to the end of the experiment. There was no significant difference in ROM of distal interphalangeal joint between groups A and B at 1, 2, and 4 weeks (P  gt; 0.05). ROM of group A was superior to that of groups C and D at 2 and 4 weeks (P  lt; 0.05). The gross and histological observations showed the same result in the grading of adhesion. At 1 week, there was no significant difference in the grading of adhesion among 4 groups (P  gt; 0.05); at 2 and 4 weeks, the grading of adhesion in group A was similar to that in group B (P  gt; 0.05), and the grading of adhesion in group A was significantly slighter than that in groups C and D (P  lt; 0.05). Conclusion Seprafilm anti-adhesion membrane composed of HA derivative can prevent tendon adhesion and improve the joint function in acute tendon injury of rabbits.

Citation： ZUO Qiang,DONG Lele,FAN Jianjun.. EXPERIMENTAL STUDY ON Seprafilm ANTI-ADHESION MEMBRANE COMPOSED OF HYALURONIC ACID DERIVATIVE ON PREVENTION OF TENDON ADHESION IN RABBIT. Chinese Journal of Reparative and Reconstructive Surgery, 2011, 25(9): 1094-1098. doi: Copy