Objective To summarize the regulations of Hedgehog signal ing pathway on the prol iferation and multidifferentiation of mesenchymal stem cells (MSCs). Methods The related l iterature in recent years concerning the regulations of Hedgehog signal ing pathway on the biological characteristics of MSCs was reviewed and analyzed. Results Hedgehog signal ing pathway promoted the prol iferation of MSCs, and played a major role in the induction of osteogenic and chondrogenic differentiations, but it inhibited the adi pocytic differentiation. Conclusion The regulations of Hedgehog signal ing pathway in MSCs multidifferentiation and prol iferation could be used as the new therapeutic targets of tissue ischemia, osteoporosis, achondroplasia, obesity, and so on.
Citation： CAI Jiaqin,DENG Li. REGULATIONS OF Hedgehog SIGNALING PATHWAY ON MESENCHYMAL STEM CELLS. Chinese Journal of Reparative and Reconstructive Surgery, 2010, 24(8): 993-996. doi: Copy