JIA Guiqing , ZHANG Mingming , WU Xiaoting.
  • Department of Gastrointestional Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.;
BMSCs; Digestive tract injury; Repair and reconstruction; Review
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To investigate the effect of BMSCs on the repair of digestive tract injury and its mechanisms.Methods Recent l iterature on the effect of BMSCs on the repair of digestive tract injury was reviewed. Results BMSCs had the potency of self-repl ication, prol iferation and multipotential differentiation, which played an important role in the repair of digestive tract injury. The probable mechanisms included: BMSCs’ abil ity of migrating to the injured tissue and inhibiting the host immune response; BMSCs’ dedifferentiation and redifferentiation; BMSCs’ direct differentiation into the epithel ial cells
or the stem cells of digestive tract; BMSCs’ fusion with the stem cells or the mature epithel ial cells of digestive tract; BMSCs’ participation in the reconstruction of injured microenvironment. Conclusion BMSCs participates in the repair of digestive tract injury and has a bright future in the treatment of digestive system disease.

Citation： JIA Guiqing,ZHANG Mingming,WU Xiaoting.. REPAIR EFFECT OF BMSCs ON DIGESTIVE TRACT INJURY. Chinese Journal of Reparative and Reconstructive Surgery, 2009, 23(6): 751-754. doi: Copy