DUAN Xiaohong 1 , CUI Pengcheng 1 , JIANG Xun 2
  • 1Department of Otolaryngology, 2Department of Pediatrics, Tangdu Hospital, the Fourth Mil itaryMedical University, Xi’an Shaanxi, 710038, P.R. China.;
Indoleamine 2,3-dioxygenase; Gene transfection; Transplantation immunity
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【Abstract】 Objective To review the research progress of possible mechanism of indoleamine 2, 3-dioxygenase
(IDO) in immunological regulation and function of transplantation immunity. Methods The advances in the IDO location, immunological regulatory mechanism and function of transplantation immunity were introduced based on the recent related l iterature. Results IDO played an immunoregulatory role by locally depleting tryptophan in tissue microenvironment which resulted in immunosuppression of allogeneic T-cell prol iferation. IDO cDNA was del ivered to chromosome in interesting cells by gene transfection and stimulated to express, which was associated with a prolongation in allograft survival in vivo . Conc lu sion IDO offers a new way in transplantation immunity, and this provid novel method for elevating allograft survival rate.

Citation： DUAN Xiaohong,CUI Pengcheng,JIANG Xun. EFFECT OF INDOLEAMINE 2,3-DIOXYGENASE ON TRANSPLANTATION IMMUNITY. Chinese Journal of Reparative and Reconstructive Surgery, 2008, 22(2): 230-233. doi: Copy