ZHANG Wenxian , WANG Yujun , WANG Xiaoyan , LV Jianghong.
  • Department of Orthopedics, Traditional Chinese Medicine Hospital, Lanzhou Gansu, 730050, P.R.China;
Spinal injury; Neural stem cells; Signal transduction
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To summarize Notch, basic hel ix-loop-hel ix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells. Methods The l iterature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed. Results The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the compl icated selective system among Notch, bHLH and Wnt gene signal transduction pathways. Conclusion At present, the specific gene signal transduction pathway of multi pl ication and differentiation of neural stem cells is still unclear.

Citation： ZHANG Wenxian,WANG Yujun,WANG Xiaoyan,LV Jianghong.. RESEARCH PROGRESS OF NEURAL STEM CELLS SIGNAL TRANSDUCTION PATHWAY. Chinese Journal of Reparative and Reconstructive Surgery, 2008, 22(4): 492-495. doi: Copy