FU Yong , YU Fengxu , LIAO Bin.
  • Department of Thoracic and Cardiovascular Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan, 646000, P.R.China.;
Cell transplantation; Biological pacemaker; Cardiac
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To review the current status and problems in developing cardiac biological pacemaker
(CBP) by cell transplantation. Methods The l iterature over the past decade concerning CBP constructed through cell
transplantation was reviewed and summarized. Results Experiments in vivo testified that the cell transplantation was feasible for CBP construction, and the transplantation of sinus atrial node cell and stem cell was still the predominant method for constructing CBP. However, such problems as difficult ampl ification of transferred cardio muscle cell, low success rate of CBP construction as well as unstable function of CBP make it lag behind the tremendous cl inical demands. The gene transfection technology might be one of the approaches to resolve these issues. Conclusion As one feasible method for CBP construction, the cell transplantation has a bright future in the cl inical appl ication and is worthy of further study.

Citation： FU Yong,YU Fengxu,LIAO Bin.. RESEARCH PROGRESS IN CARDIAC BIOLOGICAL PACEMAKER CREATED BY CELL TRANSPLANTATION. Chinese Journal of Reparative and Reconstructive Surgery, 2008, 22(9): 1135-1138. doi: Copy