• Tissue Engineering Center, Stomatological College, the Fourth Military Medical University, Xi’an, Shaanxi, 710032, P.R.China;
Basic fibroblast growth factor; Sustained-release microsphere; Collagen membrane; Wound healing; Pig
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Objective To investigate the promotion effects of the collagen membrane incorporating bFGF impregnated microspheres on the wound healing of the pigskin losing its full-thickness layers. Methods The bFGF containing microspheres was added into the dry microspleres.The collagen membranes were prepared by incorporating bFGF-impregnated microspheres, and 6 York pig models of skin wounds with loss of their full-thickness layers were established for the ob
servation of the effects on the wound healing. Results The healing time and the 28day healing rate were 27.30±1.14 days and 98.12%±1.97%, respectively.The healing rate was significantly higher and the healing time was significantl
y shorter in the experimental group than in the control group (P lt;0.05). The histological examination showed that the proliferation condition of the epidermiswasalso much better in the experimental group. Conclusion Incorporation of bFGF-impregnated microspheres into the collagen membrane is a promising method of pro
moting the healing of the wound with a loss of the fullthickness skin.

Citation： HUANG Sha,JIN Yan,DENG Tianzheng,et al.. PROMOTION OF WOUND HEALING THROUGH INCORPORATION OF bFGF-IMPREGNATED MICROSPHERES INTO COLLAGEN MEMBRANE. Chinese Journal of Reparative and Reconstructive Surgery, 2006, 20(2): 161-164. doi: Copy