Objective To examine an effect of the locally-used platelet derived growth factor-BB (PDGF-BB) on the healing of the medial collateral ligament (MCL) in the knee joints of rats. Methods Forty-eight rats were equally randomly divided into 2 groups: the experimental group (group A) and the control group(group B). MCL of all the rats were ruptured to establish the wound models. In group A, 5 μg of PDGF-BB was locally injected in the wound of each rat and then the wound was sutured; but in group B, the wound was only sutured. After 2 weeks, histological evaluations were performed to determine whether PDGF-BB could promote the healing of MCL. Results There were significantly more fibroblasts formed during the ligament healing process in group A than in group B (213.44±15.32 vs. 180.42±12.78, P lt;0.01). The fibroblasts were more mature andmore regularlyarranged in group A than in group B. The type, content, and crosslink of the collagen were improved to a greater extent in group A than in group B (P lt;0.01). Conclusion PDGF can promote the healing of the injured ligament.
Citation： REN Yizhong,LI Wenqi,LIU Xiaomin.. EFFECT OF PLATELET DERIVED GROWTH FACTOR BB ON HEALING OF MEDIAL COLLATERAL LIGAMENT IN RATS. Chinese Journal of Reparative and Reconstructive Surgery, 2006, 20(6): 616-619. doi: Copy