• Department of Plastic Surgery,Nanfang Hospital, Southern Medical University(the First Military Medical University)，Guangzhou Guangdong， 510515，P.R. China;
p53 gene; Keloid; Polymorphism; Genetic susceptibility
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Objective To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid. Methods The p53 genotypes were detected by polymerase chain reactionreverse dot blot(PCRRDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid. Results The frequency of the Proallele(P=0.035) and Pro/Pro genotype(P=0.030) in patients was significantly higher than that in the controlls. There was no significant difference in the frequency of Pro/Arg and Arg/Arg genotypes between patients and controls. Conclusion The p53 gene codon 72 polymorphism may play a role in susceptibility to keloid.

Citation： ZHUO Yang,GAO Jianhua,LUO Shenqiu,et al.. p53 GENE CODON 72 POLYMORPHISM AND SUSCEPTIBILITY TO KELOID IN CHINESE POPULATION. Chinese Journal of Reparative and Reconstructive Surgery, 2005, 19(1): 28-30. doi: Copy