Objective To investigate the current situation and developing trend of antithrombotic function study of endothelium in vasculartissue engineering. Methods The effect of several elements onthe antithrombotic ability of endothelium, including the source of endothelium,the characteristic of the matrix materials, the cell culture methods, and the endothelium’s gene modification were analyzed. Results The normal antithrombotic function of tissue engineered vascular relied on the source ofendothelium, gene modification of seeding cells, the cell culture methods in vitro, and the characteristic of the scaffolds. Conclusion The establishment of an ideal antithrombotic functional tissue engineering vascular still requires further studies in various aspects including seeding cells, matrix materials, and cell culture methods. Gene modification of vascular endothelium, which improves the antithrombotic ability, deserves more attention.

Citation： ZHENG Lei,WANG Qian.. STUDY OF ANTITHROMBOTIC FUNCTION OF ENDOTHELIUM IN VASCULAR TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2005, 19(1): 74-77. doi: Copy