• Division of Stem Cell and Tissue Engineering, State Key Laboratory ofBiotherapy, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
Abdominal wall defect; Small intestinal submucosa; Polypropylene mesh; Repair; Comparison
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Objective To compare the effect of small intestinal submucosa(SIS)and polypropylene mesh(PPM) on repairing abdominal wall defects in rats, and toprobe into the feasibility of using SIS to repair the abdominal wall defects. Methods 100 SD rats(50 males and 50 females)were randomly divided into 2 groups(n=50). Their weight ranged from 200 to 250 g.Full thickness abdominal wall defects (2 cm×2 cm) were created by surgery and were repaired with SIS and PPM respectively. At different postoperative time (1st, 2nd, 4th, 8th and 12th week), animals were sacrificed to make histological observation. The tensile strengthand the development of adhesions were measured and observed. Results 95 animals survived and were healthy after surgery. No inflammatory response and obvious immunoreaction were observed in both groups. One week after operation, the tensile strengthof abdominal wall in SIS group (204.30±5.13 mmHg) was lower than that in PPMgroup(240.0±10.0 mmHg) at 1st week(P＜0.05),and there were no difference at 4th, 8th, 12th week. Adhesions were more marked in PPM group thanthat in SIS group(P＜0.05). Conclusion Both SIS and PPM are histologically compatible when used in rats and can maintain sufficient tensile strength. SIS is superior to PPM in regards to tissue compatibility and adhesion formation.

Citation： ZHANG Xihai,LUO Jingcong,YANG Zhiming,et al.. ELEMENTARY EVALUATION OF SMALL INTESTINAL SUBMUCOSA AND POLYPROPYLENEMESH USED FOR REPAIRING ABDOMINAL WALL DEFECT IN RATS. Chinese Journal of Reparative and Reconstructive Surgery, 2005, 19(7): 574-577. doi: Copy