• Department of Orthopaedics, the Second Hospital of China Medical University, Liaoning Shenyang, 110003，P. R. China;
Bone morphogenetic protein 2; Gene therapy; Bone defect; Repair
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Objective To study the effect of direct bone morphogenetic protein 2 (BMP-2) gene therapy mediated by adenovirus on repairing bone defect. Methods The radial defect models were made on 60 rabbits, which were evenly divided into 4 groups randomly. The 4 groups were treated with different materials: group A, adenovirus carrying BMP-2 gene (AdBMP-2) plus bovine cancellous bone (BCB); group B, reconstructed BMP-2 plus BCB; group C, AdLacz plus BCB; and group D, only BCB scaffolds. The X-ray, histological examination, biomechanics analysis, and immunohistochemical staining were made 4, 8, and 12 weeks after the operation. Results Group A gained better effect in the volume of new bones, the anti-bending intensity of the healing bone, and the expression of BMP-2 than those of group B. The defect in group A was healed. No new bones were observed in group C and group D. Conclusion Direct BMP-2 gene therapy is easy to perform and has veryb osteoinduction ability. It is a good method to repair segmental bone defects.

Citation： LI Jianjun,BAI Lunhao,SUN Hongbin,et al.. DIRECT BONE MORPHOGENETIC PROTEIN 2 GENE THERAPY FOR REPAIRING SEGMENTAL RADIAL DEFECT IN RABBITS. Chinese Journal of Reparative and Reconstructive Surgery, 2005, 19(9): 725-728. doi: Copy