LI Xin 1 , HUANG Xin 2 , QI Zuoliang 1 , et al. 1
  • Department of Plastic Surgery, the Ninth People’s Hospital of Shanghai, Second Medical University. Shanghai, P. R. China 200011;
Transforming growth factor-β; Bone morphogenetic proteins; Activin; New bone formation
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Objective To review the recent advances in transforming growth factor-β(TGF-β) super family study and its role in new bone formation. Methods The latest original articles related to this subject were retrieved extensively,especially the effect of TGF-β, bone morphogenetic proteins(BMPs) and activin(ACT) on distractionosteogenesis. Results TGF-β, BMPs and ACT play important roles in prompting new bone formation and each of them has different effects. Among them, TGF-β can stimulate the proliferation of osteoblast and synthesis ofextra cellular medium; BMPs can initiate the differentiation of interstitial cell toosteocyte; then ACT displays the combine effect of above two factors. Conclusion TGF-β superfamily can regulate new bone formation and thus shorten the course of mandibular distraction osteogenesis.

Citation： LI Xin,HUANG Xin,QI Zuoliang,et al.. TRANSFORMING GROWTH FACTOR-β SUPERFAMILY IN THE REGULATION OF NEW BONE FORMATION. Chinese Journal of Reparative and Reconstructive Surgery, 2002, 16(2): 126-129. doi: Copy