OBJECTIVE: From the point of view of material science, the methods of tissue repair and defect reconstruct were discussed, including mesenchymal stem cells (MSCs), growth factors, gene therapy and tissue engineered tissue. METHODS: The advances in tissue engineering technologies were introduced based on the recent literature. RESULTS: Tissue engineering should solve the design and preparation of molecular scaffold, tissue vascularization and dynamic culture of cell on the scaffolds in vitro. CONCLUSION: Biomaterials play an important role in the tissue engineering. They can be used as the matrices of MSCs, the delivery carrier of growth factor, the culture scaffold of cell in bioreactors and delivery carrier of gene encoding growth factors.
Citation： YAO Kang de,SONG Xue feng,LIU Wen guang,et al.. ADVANCES IN RESEARCH AND DEVELOPMENT OF TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2002, 16(5): 325-328. doi: Copy